Sftpc Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sftpc
surfactant associated protein C
MGI:109517

17 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm1Ntang/Pfkfb2^tm1Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal pulmonary alveolus epithelial cell morphology	J:353628
	abnormal vital capacity	J:353628
	decreased cellular ATP level	J:353628
	decreased lung compliance	J:353628
	decreased type I pneumocyte number	J:353628
	pulmonary fibrosis	J:353628
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm2Ntang/Pfkfb2^tm2Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal susceptibility to injury induced morbidity/mortality	J:353628
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm2Ntang/Pfkfb2^tm2Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ Stk11^tm1.1Sjm/Stk11^tm1.1Sjm involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	abnormal susceptibility to injury induced morbidity/mortality	J:353628
Kras^tm4Tyj/Kras⁺ Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ Trp53^tm5Tyj/Trp53⁺ involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	abnormal pulmonary alveolus morphology	J:182218
	increased adenocarcinoma incidence	J:182218
	increased lung adenoma incidence	J:182218
	premature death	J:182218
Kras^tm4Tyj/Kras⁺ Sftpc^{tm1.1(cre/ERT2)Ptch}/Sftpc⁺ involves: 129P2/OlaHsd * C57BL/6 * FVB	increased lung adenoma incidence	J:195738
Kras^tm4Tyj/Kras⁺ Sftpc^{tm1.1(cre/ERT2)Ptch}/Sftpc⁺ Trp53^tm1Brn/Trp53^tm1Brn involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB	decreased tumor-free survival time	J:195738
	increased lung adenocarcinoma incidence	J:195738
	increased lung adenoma incidence	J:195738
	increased type II pneumocyte number	J:195738
Met^tm1Sst/Met^tm1Sst Sftpc^{tm1(cre/ERT2,rtTA)Hap}/Sftpc⁺ involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal pulmonary alveolus morphology	J:264185
	emphysema	J:264185
	overexpanded pulmonary alveolus	J:264185
Ptpra^{tm1c(EUCOMM)Hmgu}/Ptpra^{tm1c(EUCOMM)Hmgu} Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ involves: 129S6/SvEvTac * C57BL/6N	normal homeostasis/metabolism phenotype	J:300194

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/12/2026 MGI 6.24