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Sftpctm1(cre/ERT2)Blh
Targeted Allele Detail
Summary
Symbol: Sftpctm1(cre/ERT2)Blh
Name: surfactant associated protein C; targeted mutation 1, Brigid L Hogan
MGI ID: MGI:5305340
Synonyms: Sftp-CreER
Gene: Sftpc  Location: Chr14:70758389-70761521 bp, - strand  Genetic Position: Chr14, 36.32 cM
Alliance: Sftpctm1(cre/ERT2)Blh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180047
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Sftpctm1(cre/ERT2)Blh expression driven by 1 gene
 
Mutation detailsAn IRES-creERT cassette, together with an FRT flanked PGK-neo cassette, were inserted into the 3' UTR. The neo selection cassette was subsequently excised by crossing to mice expressing flp recombinase. (J:180047, J:182218)
Schematic of Sftpctm1(cre/ERT2)Blh (Sftpc-CreER) allele.
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sftpc (mouse)
Summary of all recombinase alleles driven by Sftpc.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Sftpctm1(cre/ERT2)Blh
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sftpc Mutation:  23 strains or lines available
References
Original:  J:180047 Rock JR, et al., Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):E1475-83
All:  61 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory