All Phenotypes Sftpc<tm1(cre/ERT2)Blh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sftpc^{tm1(cre/ERT2)Blh}
targeted mutation 1, Brigid L Hogan
MGI:5305340

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm1Ntang/Pfkfb2^tm1Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:8329626
cn2	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm2Ntang/Pfkfb2^tm2Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ Stk11^tm1.1Sjm/Stk11^tm1.1Sjm	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:8329627
cn3	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm2Ntang/Pfkfb2^tm2Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:8329628
cn4	Kras^tm4Tyj/Kras⁺ Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ Trp53^tm5Tyj/Trp53⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5317171
cn5	Ptpra^{tm1c(EUCOMM)Hmgu}/Ptpra^{tm1c(EUCOMM)Hmgu} Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺	involves: 129S6/SvEvTac * C57BL/6N	MGI:6690444

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm1Ntang/Pfkfb2^tm1Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1205 available)
Pfkfb2^tm1Ntang mutation (0 available); any Pfkfb2 mutation (37 available)
Sftpc^{tm1(cre/ERT2)Blh} mutation (1 available); any Sftpc mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cellular ATP level ( J:353628 )

• reduced glycolytic ATP production in AT2 cells

homeostasis/metabolism

decreased cellular ATP level ( J:353628 )

• reduced glycolytic ATP production in AT2 cells

respiratory system

abnormal pulmonary alveolus epithelial cell morphology ( J:353628 )

• reduced number of AT1 cells 63 days after bleomycin-induced lung injury at age 12 months

• normal number of AT2 cells 63 days after bleomycin-induced lung injury at age 12 months

decreased type I pneumocyte number ( J:353628 )

• 63 days after bleomycin-induced lung injury at age 12 months

pulmonary fibrosis ( J:353628 )

• 63 days after bleomycin-induced lung injury at age 12 months

abnormal vital capacity ( J:353628 )

• reduced forced vital capacity 63 days after bleomycin-induced lung injury at age 12 months

decreased lung compliance ( J:353628 )

• 63 days after bleomycin-induced lung injury at age 12 months

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm2Ntang/Pfkfb2^tm2Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ Stk11^tm1.1Sjm/Stk11^tm1.1Sjm
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1205 available)
Pfkfb2^tm2Ntang mutation (0 available); any Pfkfb2 mutation (37 available)
Sftpc^{tm1(cre/ERT2)Blh} mutation (1 available); any Sftpc mutation (25 available)
Stk11^tm1.1Sjm mutation (1 available); any Stk11 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )

• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )

• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} Pfkfb2^tm2Ntang/Pfkfb2^tm2Ntang Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1205 available)
Pfkfb2^tm2Ntang mutation (0 available); any Pfkfb2 mutation (37 available)
Sftpc^{tm1(cre/ERT2)Blh} mutation (1 available); any Sftpc mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )

• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:353628 )

• reduced lung fibrosis, better forced vital lung capacity, better lung compliance and increased number of alveolar type I (AT1) cells 63 days after bleomycin-induced lung injury at age 12 months

Allelic Composition	Kras^tm4Tyj/Kras⁺ Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺ Trp53^tm5Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (11 available); any Kras mutation (71 available)
Sftpc^{tm1(cre/ERT2)Blh} mutation (1 available); any Sftpc mutation (25 available)
Trp53^tm5Tyj mutation (1 available); any Trp53 mutation (246 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:182218 )

• mice die 14 weeks or less after tamoxifen administration

neoplasm

increased lung adenoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 1dose or 4 doses of tamoxifen develop widespread adenomas in the alveoli by 14 weeks of age, but the bronchoalveolar duct junction remains tumor-free

increased adenocarcinoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 1dose or 4 doses of tamoxifen develop widespread adenocarcinomas in the alveoli by 14 weeks of age

respiratory system

increased lung adenoma incidence ( J:182218 )

• at 6-8 weeks of age, animals administered 1dose or 4 doses of tamoxifen develop widespread adenomas in the alveoli by 14 weeks of age, but the bronchoalveolar duct junction remains tumor-free

abnormal pulmonary alveolus morphology ( J:182218 )

• at 2 weeks after tamoxifen treatement, brochioalveolar duct junctions (BADJ) appear normal, but small adenomas occur in the alveoli; these progress to adenocarcinoma but the BADJ remain histologically normal

Allelic Composition	Ptpra^{tm1c(EUCOMM)Hmgu}/Ptpra^{tm1c(EUCOMM)Hmgu} Sftpc^{tm1(cre/ERT2)Blh}/Sftpc⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpra^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ptpra mutation (44 available)
Sftpc^{tm1(cre/ERT2)Blh} mutation (1 available); any Sftpc mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:300194 )

N	• bleomycin, tamoxifen-treated mice develop fibrosis and lung collagen content as in control mice

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