Sftpc^{tm1.1(cre/ERT2)Ptch}
Targeted Allele Detail

Summary

• Symbol: Sftpc^{tm1.1(cre/ERT2)Ptch}
• Name: surfactant associated protein C; targeted mutation 1.1, Pao-Tien Chuang
• MGI ID: MGI:5485991
• Synonyms: SPC^CreER
• Gene: Sftpc Location: Chr14:70758389-70761521 bp, - strand Genetic Position: Chr14, 36.32 cM
• Alliance: Sftpc^{tm1.1(cre/ERT2)Ptch} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195738
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sftpc^{tm1.1(cre/ERT2)Ptch} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sftpc (MGI:109517)

• Mutation details: The translational start ATG of the Sftpc gene was replaced with a cre/ERT Frt-PGK-neo-Frt cassette (containing 3 copies of the polyadenylation signal) by homologous recombination in ES cells. The neo marker was removed by crosses to Tg(ACTFLPe)9205 mice. (J:195738)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sftpc (mouse) Summary of all recombinase alleles driven by Sftpc. Alliance mouse Sftpc gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sftpc Mutation: 23 strains or lines available

References

• Original: J:195738 Lin C, et al., Alveolar type II cells possess the capability of initiating lung tumor development. PLoS One. 2012;7(12):e53817
• All: 2 reference(s)