Sftpc Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sftpc
surfactant associated protein C
MGI:109517

46 phenotypes from 7 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sftpc^tm1.1Mfbs/Sftpc⁺ B6.Cg-Sftpc^tm1.1Mfbs	abnormal lung development	J:267027
Sftpc^tm1.1Mfbs/Sftpc^tm1.1Mfbs B6.Cg-Sftpc^tm1.1Mfbs	abnormal lung development	J:267027
	abnormal lung saccule morphology	J:267027
	abnormal pulmonary alveolus epithelial cell morphology	J:267027
	perinatal lethality, complete penetrance	J:267027
Sftpc^tm1.1Xft/Sftpc⁺ Not Specified	abnormal pulmonary alveolus morphology	J:376785
Sftpc^tm1.1Xft/Sftpc^{tm1(cre/ERT2,rtTA)Hap} involves: 129 * C57BL/6 * C57BL/6J	abnormal mitochondrial physiology	J:376785
	abnormal pulmonary alveolus morphology	J:376785
	abnormal type II pneumocyte morphology	J:376785
Sftpc^tm1.1Xft/Sftpc^tm1.1Xft involves: C57BL/6J	abnormal pulmonary alveolus morphology	J:376785
Sftpc^tm1Mfbs/Sftpc⁺ Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj}/Gt(ROSA)26Sor⁺ B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj} Sftpc^tm1Mfbs	alveolitis	J:267027
	normal growth/size/body region phenotype	J:267027
	normal mortality/aging	J:267027
Sftpc^tm1Mfbs/Sftpc^tm1Mfbs B6.Cg-Sftpc^tm1Mfbs	abnormal autophagy	J:267027
	abnormal lung morphology	J:267027
	increased type II pneumocyte number	J:267027
	lung inflammation	J:267027
	pulmonary fibrosis	J:267027
	thick pulmonary interalveolar septum	J:267027
Sftpc^tm1Mfbs/Sftpc^tm1Mfbs Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj}/Gt(ROSA)26Sor⁺ B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-flpo/ERT2)Alj} Sftpc^tm1Mfbs	abnormal autophagy	J:267027
	abnormal lung morphology	J:267027
	alveolitis	J:267027
	decreased lung compliance	J:267027
	decreased survivor rate	J:267027
	hypoxemia	J:267027
	increased type II pneumocyte number	J:267027
	lung inflammation	J:267027
	pulmonary fibrosis	J:267027
	weight loss	J:267027
Sftpc^tm1Swg/Sftpc^tm1Swg either: 129 or (involves: 129 * Black Swiss)	abnormal bronchus epithelium morphology	J:82925
	abnormal lung interstitium morphology	J:82925
	abnormal lung morphology	J:82925
	abnormal lung vasculature morphology	J:82925
	abnormal pulmonary alveolus epithelial cell morphology	J:82925
	abnormal pulmonary alveolus morphology	J:82925
	abnormal pulmonary elastic fiber morphology	J:82925
	abnormal pulmonary interalveolar septum morphology	J:82925
	conjunctivitis	J:82925
	early reproductive senescence	J:82925
	emphysema	J:82925
	increased airway resistance	J:82925
	increased alveolar lamellar body number	J:82925
	increased type II pneumocyte number	J:82925
	overexpanded pulmonary alveolus	J:82925
	poor grooming	J:82925
	weight loss	J:82925
Sftpc^tm1Swg/Sftpc^tm1Swg involves: 129/Sv * Black Swiss	abnormal lung hysteresivity	J:69619
	abnormal surfactant physiology	J:69619
	normal respiratory system phenotype	J:69619
Sftpc^tm2.1Mfbs/Sftpc⁺ B6.Cg-Sftpc^tm2.1Mfbs	abnormal lung interstitium morphology	J:279196
	abnormal lung morphology	J:279196
	cyanosis	J:279196
	lung inflammation	J:279196
	overexpanded pulmonary alveolus	J:279196
	postnatal lethality, complete penetrance	J:279196
	respiratory distress	J:279196
	respiratory failure	J:279196
Sftpc^tm2Mfbs/Sftpc⁺ Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ B6.Cg-Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} Sftpc^tm2Mfbs	alveolitis	J:279196
	normal growth/size/body region phenotype	J:279196
	normal mortality/aging	J:279196
Sftpc^tm2Mfbs/Sftpc^tm2Mfbs B6.Cg-Sftpc^tm2Mfbs	normal respiratory system phenotype	J:279196
Sftpc^tm2Mfbs/Sftpc^tm2Mfbs Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ B6.Cg-Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} Sftpc^tm2Mfbs	abnormal lung morphology	J:279196
	alveolitis	J:279196
	decreased lung compliance	J:279196
	decreased type II pneumocyte number	J:279196
	hypoxemia	J:279196
	impaired autophagy	J:279196
	increased cytokine level	J:279196
	increased endoplasmic reticulum stress	J:279196
	increased lung apoptosis	J:279196
	increased transforming growth factor beta level	J:279196
	premature death	J:279196
	pulmonary fibrosis	J:279196
	weight loss	J:279196

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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