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Disease Ontology Browser
chronic obstructive pulmonary disease (DOID:3083)
Alliance: disease page
Synonyms: chronic obstructive airway disease; chronic obstructive lung disease; COLD; COPD
Alt IDs: DOID:11500, DOID:6144, EFO:0000341, ICD10CM:J44.9, MESH:D029424, NCI:C3199, OMIM:606963, UMLS_CUI:C0024117
Definition: An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.

Disease References using Mouse Models (21)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory