Tg(tetO-ERBB2*)26Kkw
Transgene Detail
|
Symbol: |
Tg(tetO-ERBB2*)26Kkw |
Name: |
transgene insertion 26, Kwok-Kin Wong |
MGI ID: |
MGI:5912483 |
Synonyms: |
tet-op-hHER2YVMA |
Transgene: |
Tg(tetO-ERBB2*)26Kkw Location: unknown
|
Alliance: |
Tg(tetO-ERBB2*)26Kkw page
|
|
|
Transgene Type: |
|
Transgenic (Inducible, Inserted expressed sequence) |
Inducer: |
|
doxycycline/tetracycline |
Mutation: |
|
Insertion
|
|
|
Tg(tetO-ERBB2*)26Kkw expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ERBB2 (2064) |
|
in-frame AYVM insertion at residue M774 |
|
|
|
Mutation details: Seven direct repeats of the tetracycline-operator (tetO) sequence drive inducible expression of the human gene with in-frame AYVM insertion at residue M774 (YVMA used because M774insAYVM and A775insYVMA lead to identical amino acid changes). Two founders were established: 26 (low copy number, high expression levels) and 5B (high copy numbers, low expression levels).
(J:143874)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:143874 Perera SA, et al., HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):474-9 |
All: |
2 reference(s) |
|