Tlr4^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tlr4^tm1Aki
• Name: toll-like receptor 4; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:1860885
• Synonyms: TLR4-, TLR4 KO, TLR4-KO
• Gene: Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
• Alliance: Tlr4^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53519
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequences encoding the transmembrane and cytoplasmic domains (amino acids 86-835) were replaced with a neomycin cassette. Northern blot analysis revealed that no mRNA is produced from this allele in splenocytes derived from homozygous mice. (J:53519, J:91950)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Tlr4 Mutation: 90 strains or lines available

References

• Original: J:53519 Hoshino K, et al., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999 Apr 1;162(7):3749-52
• All: 703 reference(s)