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Itgb6tm1Des
Targeted Allele Detail
Summary
Symbol: Itgb6tm1Des
Name: integrin beta 6; targeted mutation 1, Dean Sheppard
MGI ID: MGI:1926484
Synonyms: beta6-, Itgb6-
Gene: Itgb6  Location: Chr2:60428636-60552987 bp, - strand  Genetic Position: Chr2, 34.81 cM, cytoband C3
Alliance: Itgb6tm1Des page
Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33139
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Insertion of a neomycin gene into a coding exon of the Itgb6 gene. (J:33139)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Itgb6tm1Des
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb6 Mutation:  32 strains or lines available
References
Original:  J:33139 Huang XZ, et al., Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J Cell Biol. 1996 May;133(4):921-8
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory