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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Itgb6tm1Des
targeted mutation 1, Dean Sheppard
MGI:1926484
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Itgb6tm1Des/Itgb6tm1Des either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) MGI:3770663
hm2
Itgb6tm1Des/Itgb6tm1Des involves: 129S4/SvJae MGI:3717771
hm3
Itgb6tm1Des/Itgb6tm1Des involves: 129S4/SvJae * C57BL/6 * SJL MGI:3832435
hm4
Itgb6tm1Des/Itgb6tm1Des involves: 129S4/SvJae * C57BL/6J MGI:2175082
hm5
Itgb6tm1Des/Itgb6tm1Des involves: 129T2/SvEms MGI:3581437
cx6
Itgb6tm1Des/Itgb6tm1Des
Mmp12tm1Sds/Mmp12tm1Sds
involves: 129/Sv * 129T2/SvEms MGI:3581438
cx7
Itgb6tm1Des/Itgb6tm1Des
Tg(SFTPC-ITGB6)1Des/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:3832436


Genotype
MGI:3770663
hm1
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• treatment with angiotensin II and aldosterone reduces macrophage invasion where as it increases macrophage invasion in wild-type mice
• tubulointerstitial damage and fibrosis induction are less than in wild-type mice following kidney obstruction




Genotype
MGI:3717771
hm2
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal vascular development in Tgfb1tm1Jmu/Tgfb1tm1Jmu mice and fewer Langerhans cells in Tgfb1tm1Jmu/Tgfb1tm1Jmu and Itgb6tm1Des/Itgb6tm1Des mice

immune system
• Langerhans cells are less abundant in back epidermis
• Langerhans cells are absent from ear epidermis
• mild inflammation occurs in the lung and skin

hematopoietic system
• Langerhans cells are less abundant in back epidermis
• Langerhans cells are absent from ear epidermis




Genotype
MGI:3832435
hm3
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
• increased numbers of eosinophiles recovered by bronchoalveolar lavage

immune system
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles
• increased numbers of eosinophiles recovered by bronchoalveolar lavage




Genotype
MGI:2175082
hm4
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Juvenile baldness in Itgb6tm1Des/Itgb6tm1Des mice

respiratory system
• mice exhibit increased airway responsiveness to acetylcholine
• mononuclear cells consisting of a mixed lymphocyte infiltrate are present in the lung epithelium
• however, mice do not display any overt signs of lung infection

immune system
• mice exhibit increased airway responsiveness to acetylcholine

integument
• mice fail to develop hair on the tops of their heads, the backs of their necks and the inner surface of their thighs
• however, by 20 to 30 days hair growth on the head and neck resumes
• degenerating follicle cells are surrounded by mononuclear cells consisting of a macrophage infiltrate
• mixed cellular infiltration of dermis, macrophages; mixed cellular infiltration of airway walls, mixed lymphocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
asthma DOID:2841 OMIM:600807
J:33139




Genotype
MGI:3581437
hm5
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Genetic
Background
involves: 129T2/SvEms
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• normal alveolar size at 2 months of age, however spontaneously developed progressive alveolar enlargement over time
• developed pulmonary emphysema over time

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pulmonary emphysema DOID:9675 OMIM:130700
J:89578




Genotype
MGI:3581438
cx6
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Mmp12tm1Sds/Mmp12tm1Sds
Genetic
Background
involves: 129/Sv * 129T2/SvEms
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
Mmp12tm1Sds mutation (1 available); any Mmp12 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

respiratory system
N
• did not exhibit alveolar enlargement and did not develop emphysema
• degree of lung inflammation was similar to that in single homozygous Itgb6 mutant mice

integument
• developed patchy juvenile baldness associated with skin inflammation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT pulmonary emphysema DOID:9675 OMIM:130700
J:89578




Genotype
MGI:3832436
cx7
Allelic
Composition
Itgb6tm1Des/Itgb6tm1Des
Tg(SFTPC-ITGB6)1Des/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
Tg(SFTPC-ITGB6)1Des mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
N
• bronchoalveolar lavage abnormalities are largely corrected
• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined
• less frequent than in mice only homozygous for Itgb6tm1Des

immune system
• accumulation of lymphocytes around conducting airways and adjacent veins found in 6 of 14 mice examined
• less frequent than in mice only homozygous for Itgb6tm1Des

integument
• inflammatory baldness observed





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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory