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Targeted Allele Detail
Symbol: Rbl2tm2Tyj
Name: RB transcriptional corepressor like 2; targeted mutation 2, Tyler Jacks
MGI ID: MGI:3706581
Synonyms: p1302lox, p130conditional, p130lox
Gene: Rbl2  Location: Chr8:91796685-91850472 bp, + strand  Genetic Position: Chr8, 44.25 cM
Alliance: Rbl2tm2Tyj page
Germline Transmission:  Earliest citation of germline transmission: J:119919
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector was used to introduce lox2722 sites on either side of exon 2, and place a hygromycin resistance cassette with a 3' loxP site in intron 2. Hygromycin was excised in vitro using Cre plasmid. (J:119919)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Tumor Data
List all tumor models in MMHCdb carrying Rbl2tm2Tyj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rbl2 Mutation:  33 strains or lines available
Original:  J:119919 MacPherson D, et al., Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification. EMBO J. 2007 Feb 7;26(3):784-94
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory