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Mecp2
Gene Detail
Symbol

Name
ID
Mecp2
methyl CpG binding protein 2
MGI:99918
Synonyms
1500041B07Rik, D630021H01Rik, Mbd5, WBP10
Feature Type
protein coding gene
Genetic Map
Chromosome X
37.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:74026592-74085690 bp, - strand
From VEGA annotation of GRCm38

  59099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MECP2
Protein SuperFamily: methyl-CpG binding protein MeCP2
Gene Tree: Mecp2

Human
homologs
MECP2, methyl CpG binding protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4204
neXtProt AC: NX_P51608

Human Synonyms: AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT

Human Chr (Location): Xq28; chrX:154021813-154097731 (-)  GRCh38.p2

Disease Associations: (6) Diseases Associated with Human MECP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(9) Targeted(28) Transgenic(7)
Incidental mutations (data from APF )
 
Female mice homozygous or male mice hemizygous for a null allele exhibit premature death, behavioral and neurological abnormalities, abnormal nervous system phenotypes, abnormal breathing, and abnormal hearing. Heterozygous mice exhibit similar behavioral and neurological abnormalities.
 
Human Diseases Modeled in Mice Using Mecp2 (1)    Mutations Annotated to Human Diseases (17)    Phenotype Images(5)
Interactions
Mecp2 interacts with 581 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (117 annotations)
Process adult locomotory behavior, behavioral fear response, ...
Component cell, cytoplasm, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (531)    Tissues (285)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 398
Northern blot 5
RT-PCR 128
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mecp2 ; ZFIN mecp2    NEW 
Molecular
reagents
All nucleic(29) Genomic(4) cDNA(19) Primer pair(6)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017654 (Evidence)
Ensembl Gene Model ENSMUSG00000031393 (Evidence)
Entrez Gene 17257 (Evidence)
DFCI TC1586636, TC1598733, TC1607941, TC1633850
DoTS DT.527643, DT.87026476, DT.94339565
NIA Mouse Gene Index U039465, U339049
Consensus CDS Project CCDS41016.1, CCDS41017.1
International Mouse Phenotyping Consortium Status Mecp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017654 VEGA Gene Model | MGI Sequence Detail 59099 C57BL/6J ±  kb
transcript OTTMUST00000043832 VEGA | MGI Sequence Detail 1739 Not Applicable 
polypeptide OTTMUSP00000019680 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017956 AT hook, DNA-binding motif
InterPro IPR016177 DNA-binding, integrase-type
InterPro IPR017353 Methyl-CpG binding protein MeCP2
InterPro IPR001739 Methyl-CpG DNA binding
Protein Ontology PR:000010277 methyl-CpG-binding protein 2
References
(Earliest) J:10374 Klemsz MJ, et al., The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene [see comments]. Cell. 1990 Apr 6;61(1):113-24
(Latest) J:221674 Su SH, et al., MeCP2 in the rostral striatum maintains local dopamine content critical for psychomotor control. J Neurosci. 2015 Apr 15;35(15):6209-20
All references(308)
Disease annotation references (29)
Other
accession IDs
MGD-MRK-16719, MGI:2148036, MGI:2442482, MGI:2442970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory