Mecp2
Gene Detail

Symbol Name ID

Mecp2 methyl CpG binding protein 2 MGI:99918

Synonyms

1500041B07Rik, D630021H01Rik, Mbd5, WBP10

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

ChrX:74026592-74085690 bp, - strand From VEGA annotation of GRCm38   59099 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: methyl-CpG binding protein MeCP2
Gene Tree: Mecp2

Human homologs

Human Homolog		MECP2, methyl CpG binding protein 2 (Rett syndrome)
NCBI Gene ID		4204
neXtProt AC		NX_P51608
Human Synonyms		AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT
Human Chr (Location)		Xq28; chrX:153287264-153363188 (-)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human MECP2

Alleles and phenotypes

All alleles(30) : Targeted(21) Gene trapped(9)
 

Female mice homozygous or male mice hemizygous for a null allele exhibit premature death, behavioral and neurological abnormalities, abnormal nervous system phenotypes, abnormal breathing, and abnormal hearing. Heterozygous mice exhibit similar behavioral and neurological abnormalities.

 
Human Diseases Modeled Using Mouse Mecp2 (1)    Alleles Annotated to Human Diseases(8)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (107 annotations)

Process	adult locomotory behavior, behavioral fear response, ...
Component	cytoplasm, cytosol, ...
Function	chromatin binding, chromatin DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (26 records)
Data Summary: Results (482)    Tissues (228)    Images (31)
Theiler Stages: 8, 9, 13, 15, 17, 18, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	349
Northern blot	5
RT-PCR	128

cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(4) cDNA(19) Primer pair(6)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000017654 (Evidence)
Ensembl Gene Model	ENSMUSG00000031393 (Evidence)
Entrez Gene	17257 (Evidence)
DFCI	TC1586636, TC1598733, TC1607941, TC1633850
DoTS	DT.527643, DT.87026476, DT.94339565
NIA Mouse Gene Index	U039465, U339049
Consensus CDS Project	CCDS41016.1, CCDS41017.1
International Mouse Knockout Project Status	Mecp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017654	VEGA Gene Model | MGI Sequence Detail	59099	C57BL/6J
transcript	OTTMUST00000043832	VEGA | MGI Sequence Detail	1739	Not Applicable
polypeptide	OTTMUSP00000019680	VEGA | MGI Sequence Detail	501	Not Applicable

All sequences(57) RefSeq(4) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017956	AT hook, DNA-binding motif
InterPro	IPR016177	DNA-binding, integrase-type
InterPro	IPR017353	Methyl-CpG binding protein MeCP2
InterPro	IPR001739	Methyl-CpG DNA binding
Protein Ontology	PR:000010277	methyl-CpG-binding protein 2

References

(Earliest) J:10374 Klemsz MJ, et al., The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene [see comments]. Cell. 1990 Apr 6;61(1):113-24
(Latest) J:194298 McLeod F, et al., Reduced seizure threshold and altered network oscillatory properties in a mouse model of Rett syndrome. Neuroscience. 2013 Feb 12;231:195-205
All references(250)

Other accession IDs

MGD-MRK-16719, MGI:2148036, MGI:2442482, MGI:2442970