About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3624674
Allelic
Composition
Mecp2tm1.1Jae/Y
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Jae mutation (2 available); any Mecp2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death

behavior/neurological
• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age
• seen at 5 weeks of age
• exhibit body trembling at 5 weeks of age
• at late stages of disease, mutants tremble when handled
• seen at late stages of disease

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 9 weeks of age
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed

growth/size/body
• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease
• 8 of 17 become overweight and obese at 40-60 days of age

homeostasis/metabolism
• frequently display cold extremities

respiratory system
• occasionally show heavy breathing at 5 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:67909


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory