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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mecp2
methyl CpG binding protein 2
MGI:99918
51 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bdnftm3Jae/Bdnf+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J 		premature death J:106973
Bdnftm3Jae/Bdnftm3Jae
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J 		abnormal action potential J:106973
lethargy J:106973
premature death J:106973
Col1a1tm8(CAG-BDNF)Jae/Col1a1+
Mecp2tm1.1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * C57BL/6 * CBA/J 		abnormal action potential J:106973
normal behavior/neurological phenotype J:106973
decreased brain weight J:106973
premature death J:106973
Mapttm1(Mecp2)Jae/Mapt+
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:89593
Mapttm1(Mecp2)Jae/Mapt+
Mecp2tm1.1Jae/Mecp2+
involves: 129S4/SvJae * C57BL/6 		normal behavior/neurological phenotype J:89593
normal growth/size/body region phenotype J:89593
normal nervous system phenotype J:89593
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
B6.Cg-Mapttm1(Mecp2)Jae 		abnormal associative learning J:182685
abnormal contextual conditioning behavior J:182685
abnormal cued conditioning behavior J:182685
abnormal miniature excitatory postsynaptic currents J:182685
abnormal object recognition memory J:182685
decreased body weight J:182685
enhanced paired-pulse facilitation J:182685
impaired coordination J:182685
increased anxiety-related response J:182685
reduced long-term potentiation J:182685
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
involves: 129/Sv * C57BL/6 		abnormal sexual interaction J:89593
ataxia J:89593
cachexia J:89593
cataract J:89593
disheveled coat J:89593
excessive scratching J:89593
impaired balance J:89593
normal mortality/aging J:89593
postnatal growth retardation J:89593
tremors J:89593
Mapttm1(Setdb1)Akba/Mapt+
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N 		impaired coordination J:178512
premature death J:178512
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N 		impaired coordination J:178512
premature death J:178512
Mbd2tm1Bh/Mbd2tm1Bh
Mecp2tm1.1Bird/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal motor capabilities/coordination/movement J:67910
premature death J:67910
Mecp2em1Dkatz/Mecp2+
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J 		abnormal locomotor behavior J:101977
normal reproductive system phenotype J:101977
Mecp2em1Dkatz/Mecp2em1Dkatz
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J 		female infertility J:101977
Mecp2em1Dkatz/Y
Tyrc-ch/Tyrc-ch
FVB.Cg-Pde6b+ Tyrc-ch Mecp2em1Dkatz/J 		premature death J:101977
Mecp2tm1.1Bird/Y
SqleSum3-Jus/Sqle+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		abnormal body weight J:198551
abnormal locomotor activation J:198551
decreased startle reflex J:198551
dermatitis J:198551
extended life span J:198551
impaired coordination J:198551
increased pulmonary respiratory rate J:198551
lethargy J:198551
limb grasping J:198551
malocclusion J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum1M1Jus/Sum1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		extended life span J:198551
normal growth/size/body region phenotype J:198551
lethargy J:198551
limb grasping J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum2M1Jus/Sum2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		abnormal body weight J:198551
dermatitis J:198551
extended life span J:198551
eye inflammation J:198551
lethargy J:198551
limb grasping J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum4M1Jus/Sum4+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		dermatitis J:198551
extended life span J:198551
eye inflammation J:198551
normal growth/size/body region phenotype J:198551
lethargy J:198551
limb grasping J:198551
malocclusion J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Sum5M1Jus/Sum5+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J 		abnormal body weight J:198551
extended life span J:198551
eye inflammation J:198551
lethargy J:198551
limb grasping J:198551
tremors J:198551
Mecp2tm1.1Bird/Y
Tg(MECP2)1Hzo/0
involves: 129P2/OlaHsd * FVB 		normal behavior/neurological phenotype J:94407
normal mortality/aging J:94407
normal nervous system phenotype J:126964
Mecp2tm1.1Bird/Y
Tg(MECP2*G273X/GFP)AHzo/0
involves: 129P2/OlaHsd * FVB 		abnormal brain development J:194039
abnormal cerebral cortex morphology J:194039
abnormal gait J:194039
abnormal hippocampus morphology J:194039
decreased brain weight J:194039
increased body weight J:194039
premature death J:194039
tremors J:194039
Mecp2tm1.1Bird/Y
Tg(MECP2*R270X/GFP)AHzo/0
involves: 129P2/OlaHsd * FVB 		abnormal brain development J:194039
abnormal cerebral cortex morphology J:194039
abnormal gait J:194039
abnormal hippocampus morphology J:194039
decreased brain weight J:194039
disheveled coat J:194039
increased body weight J:194039
premature death J:194039
tremors J:194039
Mecp2tm1.1Meg/Y
B6.129-Mecp2tm1.1Meg 		abnormal dendrite morphology J:178533
abnormal response to novel object J:178533
abnormal response to novelty J:178533
normal behavior/neurological phenotype J:178533
increased miniature inhibitory postsynaptic current amplitude J:178533
normal reproductive system phenotype J:178533
Mecp2tm1.1Meg/Mecp2tm1.1Meg
B6.129-Mecp2tm1.1Meg 		normal reproductive system phenotype J:178533
Mecp2tm1Jae/Y
Tg(Camk2a-Setdb1)1Akba/0
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL 		decreased body weight J:178512
decreased locomotor activity J:178512
impaired coordination J:178512
premature death J:178512
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory