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Tyrc-ch
Spontaneous Allele Detail
Summary
Symbol: Tyrc-ch
Name: tyrosinase; chinchilla
MGI ID: MGI:1855977
Synonyms: cch, cr
Gene: Tyr  Location: Chr7:87073979-87142637 bp, - strand  Genetic Position: Chr7, 49.01 cM
Alliance: Tyrc-ch page
Tyrc/Tyrc and Tyrc/Tyrc-ch Oca2p/ Oca2p

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  fancier's stock
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe mutation in the chinchilla allele was found to be a G-to-A point mutation that results in an amino acid change at position 482 or 464 from alanine to threonine (p.A482T for pre-protein, p.A464T for mature protein). (J:19279)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tyrc-ch
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 79 strains available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:  379 strains or lines available
References
Original:  J:14850 Feldman HW, A fourth allelomorph in the albino series in mice. Am Naturalist. 1922;56:573-574
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory