Mecp2^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1Jae
• Name: methyl CpG binding protein 2; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:2158353
• Synonyms: Mecp^2lox
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67909
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 3 as follows: A single loxP site was inserted 5' to exon 3 and a loxP-flanked hygromycin and thymidine kinase selection cassette was inserted 3' to exon 3. The selection cassette was removed in ES cells by Cre-mediated recombination prior to the production of chimeric mice, leaving a single loxP site in place of the selection cassette. (J:67909)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:67909 Chen RZ, et al., Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat Genet. 2001 Mar;27(3):327-31
• All: 31 reference(s)