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Phenotypes Associated with This Genotype
Genotype
MGI:7266284
Allelic
Composition
Mecp2tm1.1Bird/Y
Genetic
Background
involves: 129P2/OlaHsd * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Bird mutation (1 available); any Mecp2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• P30 males exhibit working memory defects, showing decreased percentage of correct alternation in the spontaneous alternation test
• males exhibit decreased latency to fall off the rotarod indicating motor impairment
• P30 males exhibit decreased grip strength
• gait analysis indicates smaller strides in P30 males

muscle
• males show increased muscle fatigue at constant speed on the rotarod

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:268051


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory