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Phenotypes Associated with This Genotype
Genotype
MGI:5751716
Allelic
Composition
Mecp2tm1.1Irsf/Mecp2+
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Irsf mutation (1 available); any Mecp2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show increased footslips in the parallel rod walking task and impaired ability to learn the accelerating rotating rod walking task at 17 weeks of age
• however, no difference is seen in the motor coordination task of dowel hang time and mice exhibit normal behaviors in the elevated plus maze
• two mice show tonic-clonic seizures followed by death after handling

respiratory system
• 8 month old mice exhibit increased breathing rate when exposed to a hypoxic gas challenge

cardiovascular system
• increase in heart weight by 8 months
• 8 month old mice show increased corrected QT interval time

growth/size/body
• increase in heart weight by 8 months
• mice become overweight by 10 weeks of age
• increase in liver weight by 8 months of age

liver/biliary system
• increase in liver weight by 8 months of age

mortality/aging
• median survival of 224 days

nervous system
• two mice show tonic-clonic seizures followed by death after handling

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:220859


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory