Phenotypes Associated with This Genotype

Genotype
MGI:3817461

• Allelic Composition: Mecp2^tm1Bird/Y
• Genetic Background: (129S6.129P2-Mecp2^tm1Bird x C57BL/6)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:135825 )

♂N • no early mortality is observed in contrast to Mecp2-null animals

growth/size/body

increased body weight ( J:135825 )

♂ • Background Sensitivity: a mild increase (animals are about 1 gram heavier) is observed relative to wild-type or F1 mutants from an FVB/N cross

behavior/neurological

decreased startle reflex ( J:135825 )

♂ • mice have a decreased startle response relative to wild-type

impaired coordination ( J:135825 )

♂ • Background Sensitivity: mice display impaired performance in coordination tasks like the rotating rod, hanging wire, and dowel walking tests

abnormal touch/ nociception ( J:135825 )

♂ • mutants exhibit deficit in pain recognition rather than significant defect in pain sensitivity

increased thermal nociceptive threshold ( J:135825 )

♂ • mice show increased latency in the hot plate assay

abnormal nest building behavior ( J:135825 )

♂ • mice show deficits in nest-building relative to wild-type, with fewer animals building or completing nests than wild-type animals over the same time period

abnormal social investigation ( J:135825 )

♂ • mice have altered social behavior and spend more time than wild-type animals interacting with an unfamiliar mouse or with a 'familiar' mouse that has been reintroduced into the cage

nervous system

decreased prepulse inhibition ( J:135825 )

♂ • mice show decreased prepulse inhibition at 74 and 82 decibels compared to wild-type

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:135825