Mecp2^tm3Meg
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm3Meg
• Name: methyl CpG binding protein 2; targeted mutation 3, Michael E Greenberg
• MGI ID: MGI:5538511
• Synonyms: MeCP2^T308A
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm3Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204723
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A point mtuation (ACC to GCC) results in the amino acid substitution of alanine for threonine at position 308 (T308A). (J:204723)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:204723 Ebert DH, et al., Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR. Nature. 2013 Jul 18;499(7458):341-5
• All: 1 reference(s)