Phenotypes Associated with This Genotype

Genotype
MGI:5568998

• Allelic Composition: Mecp2^tm1.1Jtc/Mecp2⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:209637 )

♀ • object memory is intact at 1 hour, but impaired at 24 hours after object training, however, the impairment occurs to a lesser degree than in males

increased fear-related response ( J:209637 )

♀ • females freeze for a larger percentage of time during the acquisition phase of the associative fear conditioning task as compared to wild type on day 80, but not on postnatal day 40

impaired coordination ( J:209637 )

♀ • reduced latency to fall from rotarod as compared to wild type on postnatal day 30

decreased locomotor activity ( J:209637 )

♀ • reduced ambulatory movements (two consecutive beam breaks) as compared to wild type on postnatal day 63

♀ • reduced fine motor movements (repeated breaking of same beam) as compared to wild type on postnatal day 63

tonic-clonic seizures ( J:209637 )

♀ • tonic-clonic seizures observed in 3.7% (5/136) of females

♀ • seizures appear to be stimulated by touch

♀ • mice die within a month of seizures

growth/size/body

decreased body weight ( J:209637 )

♀ • reduced body weight as compared to wild type on postnatal day 64

nervous system

tonic-clonic seizures ( J:209637 )

♀ • tonic-clonic seizures observed in 3.7% (5/136) of females

♀ • seizures appear to be stimulated by touch

♀ • mice die within a month of seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:209637