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Phenotypes Associated with This Genotype
Genotype
MGI:5538526
Allelic
Composition		 Mecp2tm3Meg/Y
Genetic
Background		 B6.129-Mecp2tm3Meg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm3Meg mutation (0 available); any Mecp2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:204723 )
• mice treated with pentylenetetrazol (PTZ) exhibit earlier onset time and frequency of tonic-clonic seizures compared with wild-type mice
impaired coordination ( J:204723 )
• on a rotarod

nervous system
increased susceptibility to pharmacologically induced seizures ( J:204723 )
• mice treated with pentylenetetrazol (PTZ) exhibit earlier onset time and frequency of tonic-clonic seizures compared with wild-type mice

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
 J:204723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory