Mecp2^tm1Pplt
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm1Pplt
• Name: methyl CpG binding protein 2; targeted mutation 1, Patrick P L Tam
• MGI ID: MGI:3800596
• Synonyms: Mecp2^tm1neoTam, Mecp2^tm1Tam
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm1Pplt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137513
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2 kb segment containing exon 3 through the first 170 bp of exon 4 and encoding the methyl-CpG-binding domain was replaced with a floxed neo cassette. The neo cassette was removed by germ line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis in brain and lung extracts. (J:137513)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:137513 Pelka GJ, et al., Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain. 2006 Apr;129(Pt 4):887-98
• All: 6 reference(s)