Phenotypes for Mecp2 MGI:3801487 MGI Mouse

mortality/aging

premature death ( J:137513 )

• 50% lethality by 8 weeks

growth/size/body

weight loss ( J:137513 )

• marked weight loss starting about 1 week before death

postnatal growth retardation ( J:137513 )

• failure to thrive after 5 weeks

• mean weight 15 g at 8 weeks comppared to 21 g for controls

behavior/neurological

behavior/neurological phenotype ( J:137344 )

N	• general locomotion is normal through 6 weeks of age

abnormal associative learning ( J:137513 )

abnormal contextual conditioning behavior ( J:137513 )

• reduced ability to associate foot shock with context

abnormal cued conditioning behavior ( J:137513 )

• reduced ability to associate auditory cue to footshock

abnormal fear/anxiety-related behavior ( J:137513 )

decreased anxiety-related response ( J:137513 )

• as measured on an elevated + maze

abnormal motor capabilities/coordination/movement ( J:137513 )

limb grasping ( J:137513 )

• clasping of hind limbs when lifted by the tail

tremors ( J:137513 )

impaired coordination ( J:137344 , J:137513 )

• coordination remains impaired through week 9 (J:137344)

• time spent on an accelerating rotarod about 1/3 that of controls (J:137513)

• no improvement with successive trials (J:137513)

abnormal locomotor behavior ( J:137513 )

abnormal gait ( J:137513 )

• splayed limbs

decreased vertical activity ( J:137344 )

• less rearing behavior when maintained in a standard environment

decreased locomotor activity ( J:137513 )

• lower activity levels on free wheels in mice before onset of breathing problems or seizures

sporadic seizures ( J:137513 )

• episodes of seizures

nervous system

sporadic seizures ( J:137513 )

• episodes of seizures

decreased brain weight ( J:137513 )

respiratory system

respiratory distress ( J:137513 )

• labored breathing

integument

disheveled coat ( J:137513 )

abnormal vibrissa morphology ( J:137513 )

• erect whiskers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Rett syndrome		DOID:1206	OMIM:312750 OMIM:613454	J:137344

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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