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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Notch1
notch 1
MGI:97363
90 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\B2mtm1Jae/\B2mtm1Jae
\Tg(LckNotch1)9Erob/?
involves: 129S2/SvPas * C57BL/6 * CBA 		increased CD8-positive, alpha-beta T cell number J:93005
lymph node hypoplasia J:93005
\Cpa3tm3(icre)Hrr/\Cpa3+
\Gt(ROSA)26Sortm1Hjf/?
\Notch1tm1Agt/\Notch1tm1Agt
involves: 129 * C57BL/6 		abnormal dendritic cell differentiation J:143731
abnormal T cell receptor beta chain V(D)J recombination J:143731
\Eogttm1.2Okaj/\Eogttm1.2Okaj
\Notch1tm1Con/\Notch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 		abnormal retina vasculature morphology J:254752
increased vascular permeability J:254752
\Eogttm1.2Okaj/\Eogttm1.2Okaj
\Notch1tm2.1Pst/\Notch1+
involves: 129/Sv * C57BL/6J * DBA/2 * SJL 		abnormal retina vasculature morphology J:254752
\Eogttm1.2Okaj/\Eogttm1.2Okaj
\Notch1tm2Pst/\Notch1+
involves: 129/Sv * C57BL/6J * DBA/2 * SJL 		abnormal retina vasculature morphology J:254752
\Fbxw7tm1.1Axbe/\Fbxw7tm1.1Axbe
\Notch1tm1Agt/\Notch1+
\Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		abnormal neuron differentiation J:166928
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Lepob/\Lepob
\Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ 		normal adipose tissue phenotype J:237232
hyperglycemia J:237232
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Ptentm1Hwu/\Ptentm1Hwu
\Tg(Adipoq-cre)1Evdr/0
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ 		abnormal brown adipose tissue morphology J:237232
normal homeostasis/metabolism phenotype J:237232
increased liposarcoma incidence J:237232
lipodystrophy J:237232
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Krastm4Tyj/\Krastm4Tyj
\Tg(Cela1-cre/ERT)1Dam/0
involves: 129S4/SvJae * 129S4/SvJaeSor 		increased pancreatic intraepithelial neoplasia incidence J:142188
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Krastm4Tyj/\Krastm4Tyj
\Tg(Pdx1-cre/Esr1*)35.10Dam/0
involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA 		increased pancreatic intraepithelial neoplasia incidence J:142188
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Rbpjtm1Hon/\Rbpjtm1Hon
\Tg(Col1a1-cre)1Kry/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N 		normal skeleton phenotype J:233131
\Gt(ROSA)26Sortm1(Notch1)Dam/\Gt(ROSA)26Sor+
\Hes1tm1.1Frad/\Hes1tm1.1Frad
\Tg(Mx1-cre)1Cgn/0
involves: 129S4/SvJaeSor * C57BL/6 * CBA 		decreased B cell number J:167000
decreased lymphoma incidence J:167000
\Jag1tm1.1Vtlr/\Jag1+
\Notch1tm2Agt/\Notch1+
involves: 129 		abnormal postnatal subventricular zone morphology J:103728
abnormal rostral migratory stream morphology J:103728
postnatal lethality, complete penetrance J:103728
\Jag1tm1Frad/\Jag1tm1Frad
\Notch1tm1Agt/\Notch1tm1Agt
\Tg(Mx1-cre)1Cgn/0
involves: 129 * C57BL/6 * CBA 		normal hematopoietic system phenotype J:98129
\Lrrn1em1Dri/\Lrrn1em1Dri
\Notch1tm2Agt/\Notch1+
involves: 129/Sv * C57BL/6J * CD-1 		abnormal cochlear inner hair cell morphology J:344891
increased cochlear inner hair cell number J:344891
\Mesp2tm5(Notch1)Ysa/\Mesp2tm5(Notch1)Ysa
involves: C57BL/6 * CBA 		abnormal vertebral arch morphology J:78989
\Mesp2tm5(Notch1)Ysa/\Mesp2tm5(Notch1)Ysa
\Psen1tm1Shs/\Psen1tm1Shs
involves: C57BL/6 * CBA 		abnormal vertebral arch morphology J:78989
\Mib1em1Jlp/\Mib1+
\Notch1tm1Con/\Notch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal cardiovascular system phenotype J:338889
\Mib1em2Jlp/\Mib1+
\Notch1tm1Con/\Notch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal aortic valve morphology J:338889
bicuspid aortic valve J:338889
normal cardiovascular system phenotype J:338889
\Notch1tm1Agt/\Notch1+
\Notch2tm1Frad/\Notch2+
\Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
\Notch1tm1Agt/\Notch1+
\Notch2tm1Frad/\Notch2tm1Frad
\Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		abnormal hair follicle melanocyte morphology J:116658
diluted coat color J:116658
normal pigmentation phenotype J:116658
\Notch1tm1Agt/\Notch1tm1Agt
\Notch2tm1Frad/\Notch2+
\Tg(Tyr-cre)2Lru/0
involves: 129/Sv * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
normal pigmentation phenotype J:116658
\Notch1tm1Agt/\Notch1tm1Agt
\Notch2tm1Frad/\Notch2tm1Frad
\Ptf1atm1(cre)Hnak/\Ptf1a+
involves: 129 * BALB/cJ 		abnormal branching involved in pancreas development J:139250
abnormal endocrine pancreas morphology J:139250
abnormal pancreas development J:139250
abnormal pancreatic acinus morphology J:139250
abnormal pancreatic bud formation J:139250
decreased pancreatic islet number J:139250
small pancreas J:139250
\Notch1tm1Agt/\Notch1tm1Agt
\Notch2tm1Frad/\Notch2tm1Frad
\Tg(Mx1-cre)1Cgn/0
involves: 129 * BALB/c * C57BL/6 * CBA 		abnormal T cell differentiation J:125373
arrested T cell differentiation J:125373
\Notch1tm1Agt/\Notch1tm1Agt
\Notch2tm1Frad/\Notch2tm1Frad
\Tg(Tyr-cre)2Lru/0
involves: 129 * BALB/c * C57BL/6 * DBA/2 		diluted coat color J:116658
\Notch1tm1Agt/\Notch1tm1Agt
\Notch2tm3Grid/\Notch2tm3Grid
\Tg(TcrAND)53Hed/?
involves: 129/Sv * 129S1/Sv * C57BL/6 * SJL 		abnormal humoral immune response J:123631
abnormal response to infection J:123631
decreased interleukin-4 secretion J:123631
\Notch1tm1Agt/\Notch1tm1Agt
\Tg(Cdh5-cre)7Mlia/0
\Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N 		abnormal atrioventricular cushion morphology J:189213
abnormal cardiac epithelial to mesenchymal transition J:189213
\Notch1tm1Con/\Notch1+
\Notch2tm3.1Rko/\Notch2tm3.1Grid
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		normal renal/urinary system phenotype J:198632
\Notch1tm1Grid/\Notch1+
\Notch4tm1Grid/\Notch4tm1Grid
involves: 129S1/Sv * C57BL/6 		postnatal growth retardation J:62571
\Notch1tm1Grid/\Notch1+
\Notch3tm1Grid/\Notch3tm1Grid
involves: 129S1/Sv * C57BL/6 		abnormal pericyte morphology J:227333
abnormal retina blood vessel morphology J:227333
abnormal retina vasculature morphology J:227333
abnormal vascular plexus formation J:227333
abnormal vascular smooth muscle morphology J:227333
abnormal venule morphology J:227333
arteriovenous malformation J:227333
impaired basement membrane formation J:227333
\Notch1tm1Grid/\Notch1tm1Grid
\Notch2tm1Grid/\Notch2tm1Grid
involves: 129S1/Sv * C57BL/6J 		abnormal direction of heart looping J:83358
abnormal left-right axis patterning J:83358
\Notch1tm1Grid/\Notch1tm1Grid
\Notch3tm1Grid/\Notch3tm1Grid
Not Specified 		abnormal developmental patterning J:87272
abnormal embryo development J:87272
abnormal embryonic tissue morphology J:87272
embryonic growth retardation J:87272
\Notch1tm1Grid/\Notch1tm1Grid
\Notch4tm1Grid/\Notch4tm1Grid
involves: 129S1/Sv * C57BL/6 		abnormal anterior cardinal vein morphology J:62571
abnormal dorsal aorta morphology J:62571
abnormal intersomitic vessel morphology J:62571
abnormal placenta vasculature J:62571
abnormal vein morphology J:62571
absent vitelline blood vessels J:62571
decreased angiogenesis J:62571
incomplete embryo turning J:62571
incomplete somite formation J:62571
open neural tube J:62571
pale yolk sac J:62571
pericardial edema J:62571
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Notch3Gt(PST033)Byg/\Notch3+
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		abnormal spleen morphology J:172442
enlarged spleen J:172442
extramedullary hematopoiesis J:172442
increased hematopoietic cell number J:172442
increased spleen red pulp amount J:172442
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * 129X1/SvJ 		absent sebaceous gland J:94517
scaly skin J:94517
thick epidermis J:94517
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA 		abnormal definitive hematopoiesis J:172442
abnormal spleen morphology J:172442
enlarged spleen J:172442
extramedullary hematopoiesis J:172442
increased hematopoietic cell number J:172442
increased leukemia incidence J:172442
increased spleen red pulp amount J:172442
\Notch1tm2Rko/\Notch1tm2Rko
\Notch2tm1Rko/\Notch2tm1Rko
\Tg(Msx2-cre)5Rem/0
involves: 129X1/SvJ * C57BL/6 * CBA 		absent hair follicle inner root sheath J:94517
absent sebaceous gland J:94517
epidermal hyperplasia J:94517
hair follicle degeneration J:94517
premature death J:94517
progressive hair loss J:94517
scaly skin J:94517
\Notch1tm2Rko/\Notch1tm2Rko
\Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg
\Tg(Msx2-cre)5Rem/0
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal hair follicle morphology J:94517
\Notch1tm6.1Rko/\Notch1+
\Notch2tm3Grid/\Notch2tm3Grid
\Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * C57BL/6 * SJL 		renal hypoplasia J:198632
\Notch1tm6.1Rko/\Notch1tm6.1Rko
\Notch2tm3Grid/\Notch2tm3Grid
\Tg(Pax3-cre)1Joe/0
involves: 129S1/Sv * C57BL/6 * SJL 		neonatal lethality, complete penetrance J:198632
renal hypoplasia J:198632
\Notch2tm1Bmc/\Notch2tm1Bmc
involves: 129S1/Sv * C57BL/6 		no abnormal phenotype detected J:107000
\Notch2tm3.1Rko/\Notch2tm3.1Rko
involves: C57BL/6 		normal renal/urinary system phenotype J:198632
\Tle5tm1Grid/\Tle5tm1Grid
\Notch1tm1Grid/\Notch1+
involves: 129S1/Sv * C57BL/6J 		postnatal growth retardation J:29516
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory