89 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
B2mtm1Jae/B2mtm1Jae Tg(LckNotch1)9Erob/? involves: 129S2/SvPas * C57BL/6 * CBA	increased CD8-positive, alpha-beta T cell number	J:93005
	lymph node hypoplasia	J:93005
Cpa3tm3(icre)Hrr/Cpa3+ Gt(ROSA)26Sortm1Hjf/? Notch1tm1Agt/Notch1tm1Agt involves: 129 * C57BL/6	abnormal dendritic cell differentiation	J:143731
	abnormal T cell receptor beta chain V(D)J recombination	J:143731
Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe Notch1tm1Agt/Notch1+ Tg(Nes-cre)1Kln/0 involves: 129 * C57BL/6 * SJL	abnormal neuron differentiation	J:166928
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Lepob/Lepob Tg(Adipoq-cre)1Evdr/0 involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ	normal adipose tissue phenotype	J:237232
	hyperglycemia	J:237232
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Ptentm1Hwu/Ptentm1Hwu Tg(Adipoq-cre)1Evdr/0 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6J * FVB/NJ	abnormal brown adipose tissue morphology	J:237232
	normal homeostasis/metabolism phenotype	J:237232
	increased liposarcoma incidence	J:237232
	lipodystrophy	J:237232
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Krastm4Tyj/Krastm4Tyj Tg(Cela1-cre/ERT)1Dam/0 involves: 129S4/SvJae * 129S4/SvJaeSor	increased pancreatic intraepithelial neoplasia incidence	J:142188
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Krastm4Tyj/Krastm4Tyj Tg(Pdx1-cre/Esr1*)35.10Dam/0 involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6 * CBA	increased pancreatic intraepithelial neoplasia incidence	J:142188
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Rbpjtm1Hon/Rbpjtm1Hon Tg(Col1a1-cre)1Kry/0 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N	normal skeleton phenotype	J:233131
Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+ Hes1tm1.1Frad/Hes1tm1.1Frad Tg(Mx1-cre)1Cgn/0 involves: 129S4/SvJaeSor * C57BL/6 * CBA	decreased B cell number	J:167000
	decreased lymphoma incidence	J:167000
Jag1tm1.1Vtlr/Jag1+ Notch1tm2Agt/Notch1+ involves: 129	abnormal postnatal subventricular zone morphology	J:103728
	abnormal rostral migratory stream morphology	J:103728
	postnatal lethality, complete penetrance	J:103728
Jag1tm1Frad/Jag1tm1Frad Notch1tm1Agt/Notch1tm1Agt Tg(Mx1-cre)1Cgn/0 involves: 129 * C57BL/6 * CBA	normal hematopoietic system phenotype	J:98129
Lrrn1em1Dri/Lrrn1em1Dri Notch1tm2Agt/Notch1+ involves: 129/Sv * C57BL/6J * CD-1	abnormal cochlear inner hair cell morphology	J:344891
	increased cochlear inner hair cell number	J:344891
Mesp2tm5(Notch1)Ysa/Mesp2tm5(Notch1)Ysa involves: C57BL/6 * CBA	abnormal vertebral arch morphology	J:78989
Mesp2tm5(Notch1)Ysa/Mesp2tm5(Notch1)Ysa Psen1tm1Shs/Psen1tm1Shs involves: C57BL/6 * CBA	abnormal vertebral arch morphology	J:78989
Mib1em1Jlp/Mib1+ Notch1tm1Con/Notch1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal cardiovascular system phenotype	J:338889
Mib1em2Jlp/Mib1+ Notch1tm1Con/Notch1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal aortic valve morphology	J:338889
	bicuspid aortic valve	J:338889
	normal cardiovascular system phenotype	J:338889
Notch1tm1Agt/Notch1+ Notch2tm1Frad/Notch2+ Tg(Tyr-cre)2Lru/0 involves: 129 * BALB/c * C57BL/6 * DBA/2	diluted coat color	J:116658
Notch1tm1Agt/Notch1+ Notch2tm1Frad/Notch2tm1Frad Tg(Tyr-cre)2Lru/0 involves: 129 * BALB/c * C57BL/6 * DBA/2	abnormal hair follicle melanocyte morphology	J:116658
	diluted coat color	J:116658
	normal pigmentation phenotype	J:116658
Notch1tm1Agt/Notch1tm1Agt Notch2tm1Frad/Notch2+ Tg(Tyr-cre)2Lru/0 involves: 129/Sv * BALB/c * C57BL/6 * DBA/2	diluted coat color	J:116658
	normal pigmentation phenotype	J:116658
Notch1tm1Agt/Notch1tm1Agt Notch2tm1Frad/Notch2tm1Frad Ptf1atm1(cre)Hnak/Ptf1a+ involves: 129 * BALB/cJ	abnormal branching involved in pancreas development	J:139250
	abnormal endocrine pancreas morphology	J:139250
	abnormal pancreas development	J:139250
	abnormal pancreatic acinus morphology	J:139250
	abnormal pancreatic bud formation	J:139250
	decreased pancreatic islet number	J:139250
	small pancreas	J:139250
Notch1tm1Agt/Notch1tm1Agt Notch2tm1Frad/Notch2tm1Frad Tg(Mx1-cre)1Cgn/0 involves: 129 * BALB/c * C57BL/6 * CBA	abnormal T cell differentiation	J:125373
	arrested T cell differentiation	J:125373
Notch1tm1Agt/Notch1tm1Agt Notch2tm1Frad/Notch2tm1Frad Tg(Tyr-cre)2Lru/0 involves: 129 * BALB/c * C57BL/6 * DBA/2	diluted coat color	J:116658
Notch1tm1Agt/Notch1tm1Agt Notch2tm3Grid/Notch2tm3Grid Tg(TcrAND)53Hed/? involves: 129/Sv * 129S1/Sv * C57BL/6 * SJL	abnormal humoral immune response	J:123631
	abnormal response to infection	J:123631
	decreased interleukin-4 secretion	J:123631
Notch1tm1Agt/Notch1tm1Agt Tg(Cdh5-cre)7Mlia/0 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ involves: 129 * 129S4/SvJaeSor * FVB/N	abnormal atrioventricular cushion morphology	J:189213
	abnormal cardiac epithelial to mesenchymal transition	J:189213
Notch1tm1Con/Notch1+ Notch2tm3.1Rko/Notch2tm3.1Grid involves: 129S1/Sv * 129X1/SvJ * C57BL/6	normal renal/urinary system phenotype	J:198632
Notch1tm1Grid/Notch1+ Notch4tm1Grid/Notch4tm1Grid involves: 129S1/Sv * C57BL/6	postnatal growth retardation	J:62571
Notch1tm1Grid/Notch1+ Notch3tm1Grid/Notch3tm1Grid involves: 129S1/Sv * C57BL/6	abnormal pericyte morphology	J:227333
	abnormal retina blood vessel morphology	J:227333
	abnormal retina vasculature morphology	J:227333
	abnormal vascular plexus formation	J:227333
	abnormal vascular smooth muscle morphology	J:227333
	abnormal venule morphology	J:227333
	arteriovenous malformation	J:227333
	impaired basement membrane formation	J:227333
Notch1tm1Grid/Notch1tm1Grid Notch2tm1Grid/Notch2tm1Grid involves: 129S1/Sv * C57BL/6J	abnormal direction of heart looping	J:83358
	abnormal left-right axis patterning	J:83358
Notch1tm1Grid/Notch1tm1Grid Notch3tm1Grid/Notch3tm1Grid Not Specified	abnormal developmental patterning	J:87272
	abnormal embryo development	J:87272
	abnormal embryonic tissue morphology	J:87272
	embryonic growth retardation	J:87272
Notch1tm1Grid/Notch1tm1Grid Notch4tm1Grid/Notch4tm1Grid involves: 129S1/Sv * C57BL/6	abnormal anterior cardinal vein morphology	J:62571
	abnormal dorsal aorta morphology	J:62571
	abnormal intersomitic vessel morphology	J:62571
	abnormal placenta vasculature	J:62571
	abnormal vein morphology	J:62571
	absent vitelline blood vessels	J:62571
	decreased angiogenesis	J:62571
	incomplete embryo turning	J:62571
	incomplete somite formation	J:62571
	open neural tube	J:62571
	pale yolk sac	J:62571
	pericardial edema	J:62571
Notch1tm2Rko/Notch1tm2Rko Notch2tm1Rko/Notch2tm1Rko Notch3Gt(PST033)Byg/Notch3+ Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	abnormal spleen morphology	J:172442
	enlarged spleen	J:172442
	extramedullary hematopoiesis	J:172442
	increased hematopoietic cell number	J:172442
	increased spleen red pulp amount	J:172442
Notch1tm2Rko/Notch1tm2Rko Notch2tm1Rko/Notch2tm1Rko Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg Tg(Msx2-cre)5Rem/0 involves: 129P2/OlaHsd * 129X1/SvJ	absent sebaceous gland	J:94517
	scaly skin	J:94517
	thick epidermis	J:94517
Notch1tm2Rko/Notch1tm2Rko Notch2tm1Rko/Notch2tm1Rko Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg Tg(Mx1-cre)1Cgn/0 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	abnormal definitive hematopoiesis	J:172442
	abnormal spleen morphology	J:172442
	enlarged spleen	J:172442
	extramedullary hematopoiesis	J:172442
	increased hematopoietic cell number	J:172442
	increased leukemia incidence	J:172442
	increased spleen red pulp amount	J:172442
Notch1tm2Rko/Notch1tm2Rko Notch2tm1Rko/Notch2tm1Rko Tg(Msx2-cre)5Rem/0 involves: 129X1/SvJ * C57BL/6 * CBA	absent hair follicle inner root sheath	J:94517
	absent sebaceous gland	J:94517
	epidermal hyperplasia	J:94517
	hair follicle degeneration	J:94517
	premature death	J:94517
	progressive hair loss	J:94517
	scaly skin	J:94517
Notch1tm2Rko/Notch1tm2Rko Notch3Gt(PST033)Byg/Notch3Gt(PST033)Byg Tg(Msx2-cre)5Rem/0 involves: 129P2/OlaHsd * 129X1/SvJ	abnormal hair follicle morphology	J:94517
Notch1tm6.1Rko/Notch1+ Notch2tm3Grid/Notch2tm3Grid Tg(Pax3-cre)1Joe/0 involves: 129S1/Sv * C57BL/6 * SJL	renal hypoplasia	J:198632
Notch1tm6.1Rko/Notch1tm6.1Rko Notch2tm3Grid/Notch2tm3Grid Tg(Pax3-cre)1Joe/0 involves: 129S1/Sv * C57BL/6 * SJL	neonatal lethality, complete penetrance	J:198632
	renal hypoplasia	J:198632
Notch2tm1Bmc/Notch2tm1Bmc involves: 129S1/Sv * C57BL/6	no abnormal phenotype detected	J:107000
Notch2tm3.1Rko/Notch2tm3.1Rko involves: C57BL/6	normal renal/urinary system phenotype	J:198632
Tle5tm1Grid/Tle5tm1Grid Notch1tm1Grid/Notch1+ involves: 129S1/Sv * C57BL/6J	postnatal growth retardation	J:29516