Notch3^{Gt(PST033)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Notch3^{Gt(PST033)Byg}
• Name: notch 3; gene trap PST033, BayGenomics
• MGI ID: MGI:3522153
• Synonyms: Notch3^{Gt(pGT1.8TM)1Wcs}, Notch3^LacZ
• Gene: Notch3 Location: Chr17:32339794-32385826 bp, - strand Genetic Position: Chr17, 17.37 cM
• Alliance: Notch3^{Gt(PST033)Byg} page

Vascular smooth muscle cell abnormalities in Gt(ROSA)26Sor^{tm3(NOTCH3*R1031C)Sat}/Gt(ROSA)26Sor⁺ Tg(Tagln-cre)1Her/0 and Gt(ROSA)26Sor^{tm2(NOTCH3*C455R)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: PST033
• Germline Transmission: Earliest citation of germline transmission: J:94517
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1TMpf
• Gene trap vector pGT1TMpf was inserted into intron 21. (J:155893)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  PST033	CC144858 ; (MGI Seq Detail)	5' RACE	Chr17:32368948-32368995 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch3 Mutation: 93 strains or lines available

References

• Original: J:67920 Leighton PA, et al., Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 2001 Mar 8;410(6825):174-9
• All: 24 reference(s)