All Phenotypes Notch3<Gt(PST033)Byg> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch3^{Gt(PST033)Byg}
gene trap PST033, BayGenomics
MGI:3522153

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}	involves: 129P2/OlaHsd	MGI:4830995
cn2	Gt(ROSA)26Sor^{tm3(NOTCH3*R1031C)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0	involves: 129 * C57BL/6 * SJL	MGI:5007810
cn3	Gt(ROSA)26Sor^{tm2(NOTCH3*C455R)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0	involves: 129 * C57BL/6 * SJL	MGI:5007812
cn4	Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0	involves: 129 * C57BL/6 * SJL	MGI:5007818
cn5	Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL	MGI:4830996
cn6	Notch1^tm2Rko/Notch1^tm2Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Msx2-cre)5Rem/0	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:3525186
cn7	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Msx2-cre)5Rem/0	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:3525189
cn8	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3⁺ Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	MGI:5009045
cn9	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA	MGI:5009039
cx10	Notch2^{Gt(LST103)Byg}/Notch2⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}	involves: 129P2/OlaHsd	MGI:4418249

Allelic Composition	Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion

nervous system

nervous system phenotype ( J:133358 )

N	• mice exhibit normal systemic physiological variables, absolute resting cerebral blood flow, and circle of Willis anatomy

increased susceptibility to ischemic brain injury ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, mice exhibit increased ischemic lesions size, more pronounced neurological deficits, a larger area of cerebral blood flow deficits, absent transient hypoperfusion episodes, and increased mortality compared with similarly treated wild-type mice

increased cerebral infarct size ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, ischemic lesions are twice as large as in similarly treated wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:133358 )

N	• mice exhibit normal systemic physiological variables, absolute resting cerebral blood flow, and circle of Willis anatomy

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:133358 )

increased cerebral infarct size ( J:133358 )

• following proximal middle cerebral artery (MCA) occlusion, ischemic lesions are twice as large as in similarly treated wild-type mice

Allelic Composition	Gt(ROSA)26Sor^{tm3(NOTCH3*R1031C)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(NOTCH3*R1031C)Sat} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:171887 )

• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3 at 1 year of age but is rescued at 3 to 6 months of age

nervous system

increased susceptibility to ischemic brain injury ( J:171887 )

• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3 at 1 year of age but is rescued at 3 to 6 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
CADASIL 1		DOID:0111035	OMIM:125310	J:171887

Allelic Composition	Gt(ROSA)26Sor^{tm2(NOTCH3*C455R)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(NOTCH3*C455R)Sat} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Vascular smooth muscle cell abnormalities in Gt(ROSA)26Sor^{tm3(NOTCH3*R1031C)Sat}/Gt(ROSA)26Sor⁺ Tg(Tagln-cre)1Her/0 and Gt(ROSA)26Sor^{tm2(NOTCH3*C455R)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0 mice

cardiovascular system

abnormal vascular smooth muscle morphology ( J:171887 )

• vascular smooth muscle cell abnormalities with intracellular inclusions are seen at 6 months of age

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:171887 )

• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3

muscle

abnormal vascular smooth muscle morphology ( J:171887 )

• vascular smooth muscle cell abnormalities with intracellular inclusions are seen at 6 months of age

nervous system

increased susceptibility to ischemic brain injury ( J:171887 )

• increased susceptibility to ischemic injury seen in Notch3 null mice is not rescued by expression of the mutant human NOTCH3

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
CADASIL 1		DOID:0111035	OMIM:125310	J:171887

Allelic Composition	Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(NOTCH3)Sat} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)
Tg(Tagln-cre)1Her mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:171887 )

N	• increased susceptibility to ischemic injury seen in Notch3 null mice is rescued by expression of the human NOTCH3

Allelic Composition	Gt(ROSA)26Sor^{tm1(NOTCH3)Sat}/Gt(ROSA)26Sor⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Tagln-cre)1Her/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased cerebral infarct size ( J:133358 )

• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3^{Gt(PST033)Byg} homozygotes

nervous system

decreased cerebral infarct size ( J:133358 )

• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3^{Gt(PST033)Byg} homozygotes

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Msx2-cre)5Rem/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2Rko mutation (3 available); any Notch1 mutation (115 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)
Tg(Msx2-cre)5Rem mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair follicle morphology ( J:94517 )

• displayed similar follicular morphologies as mutant mice homozygous for Notch1^tm1Shn expressing the Tg(Msx2-cre)5Rem transgene

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Msx2-cre)5Rem/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm2Rko mutation (3 available); any Notch1 mutation (115 available)
Notch2^tm1Rko mutation (0 available); any Notch2 mutation (97 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)
Tg(Msx2-cre)5Rem mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

integument

absent sebaceous gland ( J:94517 )

• loss of sebaceous glands in embryo-deleted follicles

thick epidermis ( J:94517 )

• had frequent acanthotic and perakeratotic scales

scaly skin ( J:94517 )

• had frequent perakeratotic scales

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

extramedullary hematopoiesis ( J:172442 )

increased hematopoietic cell number ( J:172442 )

• myeloproliferative disease

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

immune system

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

growth/size/body

enlarged spleen ( J:172442 )

Allelic Composition	Notch1^tm2Rko/Notch1^tm2Rko Notch2^tm1Rko/Notch2^tm1Rko Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg} Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:172442 )

• increase in the granulocyte/monocyte progenitors cell population

extramedullary hematopoiesis ( J:172442 )

increased hematopoietic cell number ( J:172442 )

• increase in the granulocyte/monocyte progenitors cell population

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

neoplasm

increased leukemia incidence ( J:172442 )

• similarity to chronic myelomonocytic leukemia

immune system

abnormal spleen morphology ( J:172442 )

• massive invasion of myeloid cells

enlarged spleen ( J:172442 )

increased spleen red pulp amount ( J:172442 )

growth/size/body

enlarged spleen ( J:172442 )

Allelic Composition	Notch2^{Gt(LST103)Byg}/Notch2⁺ Notch3^{Gt(PST033)Byg}/Notch3^{Gt(PST033)Byg}
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2^{Gt(LST103)Byg} mutation (0 available); any Notch2 mutation (97 available)
Notch3^{Gt(PST033)Byg} mutation (0 available); any Notch3 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:155893 )

• mice die shortly after birth

respiratory system

abnormal lung development ( J:155893 )

• myofibroblasts in the lungs exhibit reduced differentiation, as determined by sma+ expression, compared to in wild-type mice

impaired lung alveolus development ( J:155893 )

• 3 of 6 surviving mice exhibit altered alveolar development compared to wild-type mice

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