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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(NOTCH3)Sat
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Spyros Artavanis-Tsakonas
MGI ID: MGI:4830990
Synonyms: WT76
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(NOTCH3)Sat page
Germline Transmission:  Earliest citation of germline transmission: J:133358
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Gt(ROSA)26Sortm1(NOTCH3)Sat expresses 1 gene
Mutation detailsA targeting vector containing a splice acceptor site, a loxP-flanked PGK neomycin cassette, a human NOTCH3 cDNA and an IRES-nuclear GFP sequence was inserted into the GT(ROSA)26Sor locus. (J:133358)
Schematic of the Gt(ROSA)26Sortm1(NOTCH3)Sat, Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat and Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat constructs
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  820 strains or lines available
Original:  J:133358 Arboleda-Velasquez JF, et al., Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4856-61
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory