Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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normal phenotype
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• mice are viable and fertile and displayed no gross abnormalities
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Notch3Gt(PST033)Byg mutation
(0 available);
any
Notch3 mutation
(93 available)
Tg(Tagln-cre)1Her mutation
(2 available)
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nervous system
N |
• increased susceptibility to ischemic injury seen in Notch3 null mice is rescued by expression of the human NOTCH3
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(NOTCH3)Sat mutation
(1 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Notch3Gt(PST033)Byg mutation
(0 available);
any
Notch3 mutation
(93 available)
Tg(Tagln-cre)1Her mutation
(2 available)
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homeostasis/metabolism
nervous system
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• following filament middle cerebral artery occlusion, mice exhibit reduced infarct volume compared with similarly treated Notch3Gt(PST033)Byg homozygotes
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