Gt(ROSA)26Sor^tm1Hjf
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Hjf
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Hans Jorg Fehling
• MGI ID: MGI:3696099
• Synonyms: R26^tdRFP, Rosa26^flSTOP-tdRFP, ROSA26^LSL-RFP, Rosa-26-rfp, ROSA26^RFP, Rosa26-stop-DsRed, Rosa26:stopp^floxedtdRFP, Rosa^stopRFP, ROSAtdRFP, ROSA-tdRFP, R-tdRFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Hjf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117041
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: This is a reporter allele for Cre activity that expresses a non-toxic tandem-dimer red fluorescent protein (2 modified DsRed subunits covalently linked) following Cre-mediated deletion of a floxed neo/stop cassette. The targeting vector inserted in intron 1 contains a neomycin/stop codon cassette and an inverted sequence coding for tandem-dimer red fluorescent protein. Inverted pairs of loxP and loxP2272 sites are arranged around these sequences in such a way that cre expression results in excision of the neo/stop codon cassette and inverts the tandem-dimer red fluorescent protein sequence permitting its expression. (J:117041)

Expression

In Mice Carrying this Mutation:

23 assay results 2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^tm1Hjf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:117041 Luche H, et al., Faithful activation of an extra-bright red fluorescent protein in 'knock-in' Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol. 2007 Jan;37(1):43-53
• All: 202 reference(s)