Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm1Hjf
• Allele Name: targeted mutation 1, Hans Jorg Fehling
• Allele ID: MGI:3696099
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cpa3^tm3(icre)Hrr/Cpa3^+ Gt(ROSA)26Sor^tm1Hjf/? Notch1^tm1Agt/Notch1^tm1Agt	involves: 129 * C57BL/6	MGI:3829973
cn2	Itch^tm1.1Alta/Itch^tm1.1Alta Gt(ROSA)26Sor^tm1Hjf/Gt(ROSA)26Sor^+ Foxp3^tm4(YFP/icre)Ayr/Foxp3^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5563102
cn3	Gt(ROSA)26Sor^tm1Hjf/Gt(ROSA)26Sor^tm1(EYFP)Cos Tg(CMV-cre)1Cgn/0	involves: 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3696483
cn4	Gt(ROSA)26Sor^tm1Hjf/? Tg(Lck-cre)548Jxm/0	involves: C57BL/6 * SJL	MGI:3696482

Genotype
MGI:3829973

cn1

• Allelic Composition: Cpa3^tm3(icre)Hrr/Cpa3⁺; Gt(ROSA)26Sor^tm1Hjf/?; Notch1^tm1Agt/Notch1^tm1Agt
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal dendritic cell differentiation ( J:143731 )

• cell-fate mapping experiments suggest that some thymic dendritic cells are derived from DN1 T cell precursors

abnormal T cell receptor beta chain V(D)J recombination ( J:143731 )

• recombined Tcrb Dbeta1-Jbeta1 gene segments are detectable in some thymic plasmacytoid dendritic cells and lymphoid dendritic cells

hematopoietic system

abnormal dendritic cell differentiation ( J:143731 )

• cell-fate mapping experiments suggest that some thymic dendritic cells are derived from DN1 T cell precursors

abnormal T cell receptor beta chain V(D)J recombination ( J:143731 )

• recombined Tcrb Dbeta1-Jbeta1 gene segments are detectable in some thymic plasmacytoid dendritic cells and lymphoid dendritic cells

cellular

abnormal dendritic cell differentiation ( J:143731 )

• cell-fate mapping experiments suggest that some thymic dendritic cells are derived from DN1 T cell precursors

Genotype
MGI:5563102

cn2

• Allelic Composition: Itch^tm1.1Alta/Itch^tm1.1Alta; Gt(ROSA)26Sor^tm1Hjf/Gt(ROSA)26Sor⁺; Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

immune system

immune system phenotype ( J:204685 )

N • regulatory T cells exhibit normal suppressive functions and stability

increased inflammatory response ( J:204685 )

• severe

Genotype
MGI:3696483

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm1Hjf/Gt(ROSA)26Sor^tm1(EYFP)Cos; Tg(CMV-cre)1Cgn/0
• Genetic Background: involves: 129X1/SvJ * BALB/cJ * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:117041 )

• analysis of hematopoietic cells demonstrates reliable detection of YFP and RFP in same cells as well as in different cells

Genotype
MGI:3696482

cn4

• Allelic Composition: Gt(ROSA)26Sor^tm1Hjf/?; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: C57BL/6 * SJL

normal phenotype

no abnormal phenotype detected ( J:117041 )

• mice are viable; strong variation in percentage of RFP-positive T lymphocytes is observed between individual mice, as well as activation in non-T lineage cells