Lep^ob
Spontaneous Allele Detail

Summary

• Symbol: Lep^ob
• Name: leptin; obese
• MGI ID: MGI:1856424
• Synonyms: ob, ob/ob
• Gene: Lep Location: Chr6:29060220-29073875 bp, + strand Genetic Position: Chr6, 12.3 cM
• Alliance: Lep^ob page

Lep^ob/Lep^ob

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: STOCK Mlph^ln a Tgfa^wa1 Cdh23^v Ednrb^s

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: Sequencing of RT-PCR products revealed a nonsense mutation in arginine codon 105 (p.R105*) resulting from a C-to-T point mutation. The 16 kDa leptin protein, expressed predominantly in adipose tissue of normal mice, is missing from homozygous mutant mice (J:29081). (J:20512, J:29081, J:45748)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	68 assay results 22 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	47 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lep^ob

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Lep Mutation: 19 strains or lines available

References

• Original: J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
• All: 1572 reference(s)