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Targeted Allele Detail
Symbol: Notch1tm1Con
Name: notch 1; targeted mutation 1, Ronald L Conlon
MGI ID: MGI:1857230
Synonyms: N1delta1, Notch-, Notch1-, Notch1tm1Con/J, Notchdelta1
Gene: Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM
Alliance: Notch1tm1Con page
Germline Transmission:  Earliest citation of germline transmission: J:25248
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsDeletion of sequences encoding the EGF repeats 28 to 36, three Notch repeats, the transmembrane domain and CDC10/SWI6 repeats, and replacement with a neomycin gene. (J:25248)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 85 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  92 strains or lines available
Original:  J:25248 Conlon RA, et al., Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory