Ptf1a^tm1(cre)Hnak
Targeted Allele Detail

Summary

• Symbol: Ptf1a^tm1(cre)Hnak
• Name: pancreas specific transcription factor, 1a; targeted mutation 1, Hassan Nakhai
• MGI ID: MGI:3701996
• Synonyms: p48-cre, Ptf1a-cre(ex1), Ptf1a^Cre(ex1), Ptf1a^tm1(cre)Nak
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^tm1(cre)Hnak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Ptf1a^tm1(cre)Hnak expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ptf1a (MGI:1328312)

• Mutation details: Cre recombinase replaced part of exon 1. A neomycin resistance gene included in the vector was subsequently removed via transient FLP expression. (J:119184)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ptf1a (mouse) Summary of all recombinase alleles driven by Ptf1a. Alliance mouse Ptf1a gene page

Expression

In Mice Carrying this Mutation:

4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 30 strains or lines available

References

• Original: J:119184 Nakhai H, et al., Ptf1a is essential for the differentiation of GABAergic and glycinergic amacrine cells and horizontal cells in the mouse retina. Development. 2007 Mar;134(6):1151-60
• All: 51 reference(s)