All Phenotypes Ptf1a<tm1(cre)Hnak> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ptf1a^tm1(cre)Hnak
targeted mutation 1, Hassan Nakhai
MGI:3701996

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Notch1^tm1Agt/Notch1^tm1Agt Notch2^tm1Frad/Notch2^tm1Frad Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129 * BALB/cJ	MGI:3809249
cn2	Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm2Tyj Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5510703
cn3	Kras^tm4Tyj/Kras⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:5510702
cn4	Kras^tm4Tyj/Kras^tm4Tyj Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae	MGI:4818400
cn5	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae	MGI:5510701
cn6	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:5510696
cn7	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J	MGI:3814193
cn8	Gt(ROSA)26Sor^tm1Sor/? Ptf1a^tm1(cre)Hnak/Ptf1a^tm1(cre)Hnak	involves: 129S4/SvJaeSor	MGI:3702510
cn9	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac	MGI:5510695
cn10	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac	MGI:5510694
cn11	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: 129S6/SvEvTac * C57BL/6J	MGI:3814192
cn12	Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Rbpj^tm1Rsch/Rbpj^tm1Rsch	involves: 129X1/SvJ	MGI:3809248
cn13	Gt(ROSA)26Sor^{tm9(Rac1*,EGFP)Rsky}/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺	involves: C57BL/6	MGI:5510698
cn14	Rela^tm1Rsch/Rela^tm1Rsch Ptf1a^tm1(cre)Hnak/?	involves: C57BL/6	MGI:3713700

Allelic Composition	Notch1^tm1Agt/Notch1^tm1Agt Notch2^tm1Frad/Notch2^tm1Frad Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129 * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Agt mutation (0 available); any Notch1 mutation (115 available)
Notch2^tm1Frad mutation (0 available); any Notch2 mutation (97 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:139250 )

• at E14.5, the acinar compartment is reduced compared to in wild-type mice

endocrine/exocrine glands

abnormal pancreatic acinus morphology ( J:139250 )

• at E14.5, the acinar compartment is reduced compared to in wild-type mice

abnormal endocrine pancreas morphology ( J:139250 )

• the endocrine epithelium is mildly disrupted

• however, morphology of the islets is normal

decreased pancreatic islet number ( J:139250 )

• the number of islets is decreased compared to in wild-type mice

abnormal pancreas development ( J:139250 )

• mice exhibit a 25% decrease in the number of proliferating cells compared to in wild-type mice

abnormal branching involved in pancreas development ( J:139250 )

• at E13.5, pancreatic buds are less branched than in wild-type mice

abnormal pancreatic bud formation ( J:139250 )

• at E13.5, pancreatic buds are smaller than controls

small pancreas ( J:139250 )

• the pancreas is slightly smaller than in wild-type mice at P1

Allelic Composition	Kras^tm4Tyj/Kras⁺ Trp53^tm1Brn/Trp53^tm2Tyj Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)
Trp53^tm2Tyj mutation (4 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• however, treatment with a potent and selective oral pan class I PI3K inhibitor (GDC 0941) blocks tumor growth

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• however, treatment with a potent and selective oral pan class I PI3K inhibitor (GDC 0941) blocks tumor growth

Allelic Composition	Kras^tm4Tyj/Kras⁺ Raf1^tm2Bacc/Raf1^tm2Bacc Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)
Raf1^tm2Bacc mutation (0 available); any Raf1 mutation (114 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• as in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• as in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes

Allelic Composition	Kras^tm4Tyj/Kras^tm4Tyj Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:162125 )

endocrine/exocrine glands

increased pancreatic intraepithelial neoplasia incidence ( J:162125 )

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:197054 )

• pancreas of older mice exhibit some areas of fatty degeneration

• however, acinar to ductal metaplasia observed in acini from Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes is rescued in an in vitro assay

neoplasm

neoplasm ( J:197054 )

N	• pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma observed in Kras^tm4Tyj Ptf1a^tm1(cre)Hnak double heterozygotes is rescued

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Allelic Composition	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(Tva)Dsa mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:140423 )

• median survival of mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, is only 151 days compared to 485 days for controls

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, display a significantly shorter latency of pancreatic ductal adenocarcinoma development

• all infected mice develop invasive pancreatic ductal adenocarcinoma within 10 months

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• mice infected with RCASBP(A)-shTP53, which knocks down Trp53 expression, display a significantly shorter latency of pancreatic ductal adenocarcinoma development

• all infected mice develop invasive pancreatic ductal adenocarcinoma within 10 months

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/? Ptf1a^tm1(cre)Hnak/Ptf1a^tm1(cre)Hnak
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:119184 )

• die within about 3 hours of birth

vision/eye

absent amacrine cells ( J:119184 )

• lack differentiated amacrine cells at E18.5

• almost no GABAergic or glycinergic positive amacrine cells are found in retinal explants cultured for 12 days; however some syntaxin- and calbindin-positive cells do develop indicating retention of a small subpopulation of differentiated amacrine cells

abnormal retina layer morphology ( J:119184 )

• in retinal explants cultured for 12 days, syntaxin-, PKCalpha- and calbindin-positive cells are disorganized

abnormal retina neuronal layer morphology ( J:119184 )

• at E18.5, beta-gal expressing cells are found scattered in the inner retina, unlike in control mice where these cells are localized in the innermost zone of the neuroblastic layer

absent retina inner plexiform layer ( J:119184 )

• fusion of the ganglion cell layer and the neuroblastic layer results in loss of the inner plexifom layer

nervous system

absent amacrine cells ( J:119184 )

• lack differentiated amacrine cells at E18.5

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Pdpk1^tm1Mlw/Pdpk1^tm1Mlw Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa} mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Pdpk1^tm1Mlw mutation (0 available); any Pdpk1 mutation (138 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia or pancreatic ductal adenocarcinoma

Allelic Composition	Gt(ROSA)26Sor^{tm2(Pik3ca*)Dsa}/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

pancreatic acinar-to-ductal metaplasia ( J:197054 )

• massive induction of acinar to ductal metaplasia

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:197054 )

• in all mice as early as 1 month with progression in amount and grade over time

increased carcinoma incidence ( J:197054 )

• pancreatic carcinoma in situ in some mice at 9 months

increased pancreatic ductal adenocarcinoma incidence ( J:197054 )

• phenocopies metastatic pancreatic ductal adenocarcinoma that develops in mice expressing with Kras^tm4Tyj activated in the pancreas

growth/size/body

enlarged pancreas ( J:197054 )

increased pancreas weight ( J:197054 )

Allelic Composition	Gt(ROSA)26Sor^tm1(Tva)Dsa/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(Tva)Dsa mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• 19 months after infection with RCASBP(A)-Kras^G12D retrovirus 3 of 5 mice developed invasive and metastatic pancreatic ductal adenocarcinomas with 2 of the 5 developing liver and lymph node metastases

• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

increased pancreatic intraepithelial neoplasia incidence ( J:140423 )

• 9 months after infection with RCASBP(A)-Kras^G12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias

increased incidence of induced tumors ( J:140423 )

• 9 months after infection with RCASBP(A)-Kras^G12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias

• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:140423 )

• all pancreatic ductal adenocarcinomas display a ductal phenotype, an intense desmoplastic stroma and local infiltration

increased pancreatic intraepithelial neoplasia incidence ( J:140423 )

• 9 months after infection with RCASBP(A)-Kras^G12D retrovirus 4 of 5 mice developed focal ductal pancreatic lesions that closely resembled human pancreatic intraepithelial neoplasias

Allelic Composition	Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Rbpj^tm1Rsch/Rbpj^tm1Rsch
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)
Rbpj^tm1Rsch mutation (0 available); any Rbpj mutation (193 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:139250 )

• mice die by 6 to 7 days after birth

digestive/alimentary system

decreased pancreatic acinar cell number ( J:139250 )

• at E14.5, no acinar cells are detected unlike in wild-type mice

• by E18.5, few acinar cells appear in late embryonic development

abnormal digestion ( J:139250 )

• mice exhibit impaired milk digestion

growth/size/body

postnatal growth retardation ( J:139250 )

• moderate at birth

endocrine/exocrine glands

abnormal pancreas morphology ( J:139250 )

• at birth the pancreas is small and altered compared to in wild-type mice

• unlike in wild-type mice, the duodenal part of the pancreas exhibits weak branching and the splenic part exhibits no branching

decreased pancreatic acinar cell number ( J:139250 )

• at E14.5, no acinar cells are detected unlike in wild-type mice

• by E18.5, few acinar cells appear in late embryonic development

increased pancreatic alpha cell number ( J:139250 )

• at E11.5, mice exhibit an increase in glucagon producing cells

decreased pancreatic islet number ( J:139250 )

• the number of islets is decreased compared to wild-type mice

disorganized pancreatic islets ( J:139250 )

• the endocrine epithelium is disrupted with alpha cells not surrounded by beta cells and long rather than circular islet-like structures

abnormal pancreas development ( J:139250 )

• at E13.5, the pancreatic epithelial mass is reduced and pancreatic bud branching is weaker than in wild-type mice

• mice exhibit a 40% decrease in the number of proliferating cells compared to in wild-type mice

abnormal pancreatic alpha cell differentiation ( J:139250 )

• at E11.5, mice exhibit premature differentiation into endocrine cells

small pancreas ( J:139250 )

cellular

abnormal pancreatic alpha cell differentiation ( J:139250 )

• at E11.5, mice exhibit premature differentiation into endocrine cells

Allelic Composition	Gt(ROSA)26Sor^{tm9(Rac1*,EGFP)Rsky}/Gt(ROSA)26Sor⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(Rac1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197054 )

N	• mice do not develop acinar to ductal metaplasia

neoplasm

neoplasm ( J:197054 )

N	• mice do not develop pancreatic intraepithelial neoplasia

Allelic Composition	Rela^tm1Rsch/Rela^tm1Rsch Ptf1a^tm1(cre)Hnak/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (30 available)
Rela^tm1Rsch mutation (0 available); any Rela mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:122194 )

• 1 of 4 mice died 48 hours after induced pancreatitis

homeostasis/metabolism

abnormal interleukin level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, pancreatic levels of TNF-alpha are increased

abnormal response/metabolism to endogenous compounds ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, mice experience panreatitis with increased vascuolizaztion, morphologically apoptotic cells, ghost cells, edema, infiltrate and massive necrosis, increased pancreatic levels of TNF-alpha and IL-6 and lung inflammation characterized by alveolar fluid accumulation and progressive thickening, hyperemia, and neutrophil infiltration of interalveolar tissue

increased susceptibility to xenobiotic induced morbidity/mortality ( J:122194 )

• 1 of 4 mice died 48 hours after induced pancreatitis

immune system

pancreas inflammation ( J:122194 )

abnormal interleukin level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, IL-6 levels are increased

abnormal tumor necrosis factor level ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, pancreatic levels of TNF-alpha are increased

lung inflammation ( J:122194 )

• following 8 intraperitoneal injections of cerulein to induce pancreatitis, lung inflammation is characterized by alveolar fluid accumulation and progressive thickening, hyperemia, and neutrophil infiltration of interalveolar tissue

endocrine/exocrine glands

pancreas inflammation ( J:122194 )

respiratory system

lung inflammation ( J:122194 )

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