Jag1^tm1Frad
Targeted Allele Detail

Summary

• Symbol: Jag1^tm1Frad
• Name: jagged 1; targeted mutation 1, Freddy Radtke
• MGI ID: MGI:3577993
• Synonyms: J1^lox
• Gene: Jag1 Location: Chr2:136923371-136958440 bp, - strand
• Alliance: Jag1^tm1Frad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98129
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank the first two coding exons. (J:98129)

Disease models

Expression

In Mice Carrying this Mutation:	5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Jag1^tm1Frad

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jag1 Mutation: 76 strains or lines available

References

• Original: J:98129 Mancini SJ, et al., Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005 Mar 15;105(6):2340-2
• All: 19 reference(s)