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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Bax
BCL2-associated X protein
MGI:99702
117 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6 		abnormal B cell morphology J:66872
abnormal brain morphology J:66872
abnormal definitive hematopoiesis J:66872
abnormal hearing physiology J:66872
abnormal splenocyte physiology J:66872
abnormal T cell morphology J:66872
anemia J:66872
circling J:66872
decreased cellular sensitivity to gamma-irradiation J:66872
decreased physiological sensitivity to xenobiotic J:66872
enlarged lymph nodes J:66872
enlarged spleen J:66872
increased brain size J:66872
increased leukocyte cell number J:66872
increased lymphocyte cell number J:66872
increased neuron number J:66872
increased spleen red pulp amount J:66872
increased spleen white pulp amount J:66872
interdigital webbing J:66872
neonatal lethality, incomplete penetrance J:66872
seizures J:66872
thrombocytopenia J:66872
vagina atresia J:66872
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm1Sjk
involves: 129S1/Sv * 129X1/SvJ 		normal hematopoietic system phenotype J:141545
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Bcl2l1tm1.1Mam/Bcl2l1tm1.1Mam
Tg(MMTV-cre)#Mam/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB 		normal hematopoietic system phenotype J:141545
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ 		abnormal B cell number J:100463
abnormal B cell physiology J:100463
decreased marginal zone B cell number J:100463
increased B cell number J:100463
increased B-2 B cell number J:100463
increased bone marrow cell number J:100463
increased follicular B cell number J:100463
increased IgA level J:100463
increased IgG level J:100463
increased IgM level J:100463
increased immunoglobulin level J:100463
increased pre-B cell number J:100463
increased pro-B cell number J:100463
increased transitional stage B cell number J:100463
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Krastm4Tyj/Kras+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		increased adenocarcinoma incidence J:125101
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm1Sjk/Baxtm2Sjk
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal T cell differentiation J:100463
arthritis J:100463
glomerulonephritis J:100463
increased anti-double stranded DNA antibody level J:100463
increased B cell number J:100463
increased leukocyte cell number J:100463
increased lymphocyte cell number J:100463
increased susceptibility to autoimmune disorder J:100463
premature death J:100463
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		decreased thymocyte apoptosis J:220951
Bak1tm1Thsn/Bak1tm1Thsn
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)548Jxm/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		increased regulatory T cell number J:208318
Baxtm1Dlo/Baxtm1Dlo
Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
involves: 129P2/OlaHsd 		decreased neuron apoptosis J:39573
prenatal lethality, complete penetrance J:39573
Baxtm1Sjk/Bax+
KitlSl/KitlSl
Tg(Pou5f1-GFP)1Scho/?
involves: 129X1/SvJ * C3H * CD-1 * FVB 		abnormal primordial germ cell proliferation J:115283
Baxtm1Sjk/Bax+
Grid2Lc-J/Grid2+
involves: 129X1/SvJ * BALB/cByJ * C57BL/6 		abnormal cerebellar granule layer morphology J:62117
abnormal cerebellar Purkinje cell layer J:62117
ataxia J:62117
decreased cerebellar granule cell number J:62117
decreased Purkinje cell number J:62117
reduced cerebellar foliation J:62117
Baxtm1Sjk/Bax+
Bcl2l1tm1Mam/Bcl2l1tm1Mam
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		abnormal ovarian folliculogenesis J:63161
decreased male germ cell number J:63161
male infertility J:63161
Baxtm1Sjk/Bax+
Nanos2tm1Ysa/Nanos2tm1Ysa
involves: 129S1/Sv * 129X1/SvJ 		abnormal male germ cell apoptosis J:132711
azoospermia J:132711
Baxtm1Sjk/Baxtm1Sjk
Bcl2l1tm1Mam/Bcl2l1tm1Mam
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 		abnormal ovarian folliculogenesis J:63161
abnormal spermatogenesis J:63161
azoospermia J:63161
male infertility J:63161
Baxtm1Sjk/Baxtm1Sjk
Bcl2l11tm1.1Ast/Bcl2l11tm1.1Ast
B6.129-Bcl2l11tm1.1Ast Baxtm1Sjk 		abnormal seminiferous tubule epithelium morphology J:103605
arrest of male meiosis J:103605
azoospermia J:103605
male infertility J:103605
small seminiferous tubules J:103605
Baxtm1Sjk/Baxtm1Sjk
Bmpr1atm1Bhr/Bmpr1atm2.1Bhr
Tg(Sftpc-cre)1Blh/0
involves: 129 * C57BL/6 * DBA/2 * ICR 		abnormal lung development J:106392
Baxtm1Sjk/Baxtm1Sjk
Chn1tm1.1Ece/Chn1tm1.1Ece
Tg(Hlxb9-GFP)1Tmj/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		abnormal innervation J:243785
Baxtm1Sjk/Baxtm1Sjk
Col25a1tm1.1Tiwa/Col25a1+
B6.Cg-Col25a1tm1.1Tiwa Baxtm1Sjk 		abnormal phrenic nerve morphology J:206855
Baxtm1Sjk/Baxtm1Sjk
Col25a1tm1.1Tiwa/Col25a1tm1.1Tiwa
B6.Cg-Col25a1tm1.1Tiwa Baxtm1Sjk 		abnormal phrenic nerve innervation pattern to diaphragm J:206855
Baxtm1Sjk/Baxtm1Sjk
Del(18Pcdhg)1Xzw/Del(18Pcdhg)1Xzw
involves: 129X1/SvJ 		abnormal voluntary movement J:188341
neonatal lethality, complete penetrance J:188341
normal nervous system phenotype J:188341
Baxtm1Sjk/Baxtm1Sjk
Etv1tm2Tmj/Etv1tm2Tmj
involves: 129S1/Sv * 129X1/SvJ 		abnormal proprioceptive neuron morphology J:197913
increased sensory neuron number J:197913
Baxtm1Sjk/Baxtm1Sjk
Gdnftm1Rosl/Gdnf+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 		abnormal enteric neuron morphology J:82456
Baxtm1Sjk/Baxtm1Sjk
Grid2Lc-J/Grid2+
involves: 129X1/SvJ * BALB/cByJ * C57BL/6 		abnormal cerebellar granule layer morphology J:62117
abnormal cerebellar Purkinje cell layer J:62117
abnormal Purkinje cell dendrite morphology J:62117
abnormal Purkinje cell morphology J:62117
ataxia J:62117
decreased Purkinje cell number J:62117
normal nervous system phenotype J:62117
Baxtm1Sjk/Baxtm1Sjk
Hax1tm1Jni/Hax1tm1Jni
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 		premature death J:132627
Baxtm1Sjk/Baxtm1Sjk
Islr2tm1.1Ddg/Islr2tm1.1Ddg
involves: 129S6/SvEvTac * 129X1/SvJ * BALB/cJ * C57BL/6 		abnormal neuron morphology J:154926
Baxtm1Sjk/Baxtm1Sjk
KitlSl/KitlSl
Tg(Pou5f1-GFP)1Scho/?
involves: 129X1/SvJ * C3H * CD-1 * FVB 		abnormal primordial germ cell migration J:115283
abnormal primordial germ cell proliferation J:115283
Baxtm1Sjk/Baxtm1Sjk
Lama2tm1Eeng/Lama2tm1Eeng
B6.129-Baxtm1Sjk Lama2tm1Eeng 		abnormal postnatal growth/weight/body size J:94431
abnormal skeletal muscle fiber morphology J:94431
normal behavior/neurological phenotype J:94431
decreased body size J:94431
decreased body weight J:94431
extended life span J:94431
impaired skeletal muscle regeneration J:94431
increased skeletal muscle mass J:94431
Baxtm1Sjk/Baxtm1Sjk
Nanos2tm1Ysa/Nanos2tm1Ysa
involves: 129S1/Sv * 129X1/SvJ 		abnormal gametogenesis J:132711
azoospermia J:132711
Baxtm1Sjk/Baxtm1Sjk
Ngftm1Gne/Ngftm1Gne
involves: 129S7/SvEvBrd * 129X1/SvJ 		abnormal neuron morphology J:154926
abnormal sensory neuron innervation pattern J:170402
Baxtm1Sjk/Baxtm1Sjk
Ntf3tm1Jae/Ntf3tm1Jae
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal dorsal root ganglion morphology J:83461
abnormal proprioceptive neuron morphology J:83461
absent muscle spindles J:83461
Baxtm1Sjk/Baxtm1Sjk
Ntrk1tm1Apat/Ntrk1tm1Apat
involves: 129S1/Sv * 129X1/SvJ 		abnormal neuron morphology J:154926
Baxtm1Sjk/Baxtm1Sjk
Ntrk1tm2(Ntrk3)Apat/Ntrk1tm2(Ntrk3)Apat
involves: 129S1/Sv * 129X1/SvJ 		abnormal proprioceptive neuron morphology J:92099
increased muscle spindle number J:92099
Baxtm1Sjk/Baxtm1Sjk
Pcdhgtm1.1Tman/Pcdhgtm1.1Tman
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 		ataxia J:188341
decreased body size J:188341
neonatal lethality, incomplete penetrance J:188341
weakness J:188341
Baxtm1Sjk/Baxtm1Sjk
Pcdhgtm2Xzw/Pcdhgtm2Xzw
Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * SJL 		normal vision/eye phenotype J:142186
Baxtm1Sjk/Baxtm1Sjk
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal enteric neuron morphology J:159854
Baxtm1Sjk/Baxtm1Sjk
Ror2Y324C/Ror2Y324C
involves: 129X1/SvJ * C57BL/6J 		abnormal primordial germ cell migration J:179805
abnormal primordial germ cell morphology J:179805
decreased primordial germ cell number J:179805
Baxtm1Sjk/Baxtm1Sjk
Sp9tm1.1Zyan/Sp9tm1.1Zyan
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J 		decreased striatum size J:238868
normal nervous system phenotype J:238868
Baxtm1Sjk/Baxtm1Sjk
Tg(Ins2-Mirc13)E4Biat/0
involves: 129X1/SvJ * C57BL/6N 		normal endocrine/exocrine gland phenotype J:314874
normal homeostasis/metabolism phenotype J:314874
Baxtm1Sjk/Baxtm1Sjk
Tg(SOD1*G93A)1Gur/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal mitochondrial morphology J:111890
abnormal motor neuron innervation pattern J:111890
abnormal motor neuron morphology J:111890
decreased motor neuron number J:111890
gliosis J:111890
impaired coordination J:111890
premature death J:111890
Baxtm1Sjk/Baxtm1Sjk
Wnt4tm1Amc/Wnt4tm3(EGFP/cre)Amc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal oogenesis J:203797
Baxtm2Sjk/Baxtm2Sjk
Scyl2tm1.1Spel/Scyl2tm1.1Spel
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL 		normal behavior/neurological phenotype J:225808
decreased body size J:225808
normal nervous system phenotype J:225808
preweaning lethality, incomplete penetrance J:225808
Cbln1tm1Jim/Cbln1tm1Jim
Baxtm1Sjk/Baxtm1Sjk
involves: 129S7/SvEvBrd * 129X1/SvJ 		ataxia J:182277
normal nervous system phenotype J:182277
Ighatm1(Myc)Janz/Igha+
Tg(Igk-V21-Bax)1967Bvn/0
involves: 129S1/Sv * C57BL/6 * FVB/N 		abnormal B cell apoptosis J:90901
abnormal plasma cell morphology J:90901
decreased tumor-free survival time J:90901
enlarged spleen J:90901
increased IgG level J:90901
increased IgM level J:90901
increased leukemia incidence J:90901
increased plasma cell number J:90901
increased plasmacytoma incidence J:90901
Tg(IghMyc)22Bri/0
Tg(Igk-V21-Bax)1967Bvn/0
involves: C57BL/6 * FVB/N 		abnormal liver morphology J:89049
enlarged spleen J:89049
increased B cell derived lymphoma incidence J:89049
increased plasmacytoma incidence J:89049
increased transitional stage B cell number J:89049
premature death J:89049
Vdac2tm1.1Ehyc/Vdac2tm1.1Ehyc
Baxtm2Sjk/Baxtm2Sjk
Tg(Lck-cre)1Cwi/?
involves: 129X1/SvJ * C57BL/6 * DBA/2 		decreased thymocyte number J:220951
small thymus J:220951
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04/30/2024
MGI 6.23 		The Jackson Laboratory