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Ntrk1tm2(Ntrk3)Apat
Targeted Allele Detail
Summary
Symbol: Ntrk1tm2(Ntrk3)Apat
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 2, Ardem Patapoutian
MGI ID: MGI:3052071
Synonyms: TrkATrkC
Gene: Ntrk1  Location: Chr3:87685551-87702469 bp, - strand  Genetic Position: Chr3, 38.62 cM
Alliance: Ntrk1tm2(Ntrk3)Apat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92099
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting construct containing IRES, rat Ntrk3 cDNA, SV40 polyA, and a floxed PGK-neo was inserted after the first 40 bp of exon 2, deleting exons 3-6. Crossing with Actb-cre mice excised the floxed neo. Southern blot confirmed recombination. RT-PCR of dorsal root ganglia of heterozygotes shows expression of both Ntrk1 and the inserted Ntrk3. (J:92099)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  60 strains or lines available
References
Original:  J:92099 Moqrich A, et al., Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate. Nat Neurosci. 2004 Aug;7(8):812-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory