Phenotypes associated with this allele

• Allele Symbol: Ntrk1^{tm2(Ntrk3)Apat}
• Allele Name: targeted mutation 2, Ardem Patapoutian
• Allele ID: MGI:3052071
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntrk1^tm2(Ntrk3)Apat/Ntrk1^tm2(Ntrk3)Apat	involves: 129S1/Sv	MGI:3052168
cx2	Ntrk1^tm2(Ntrk3)Apat/Ntrk1^tm2(Ntrk3)Apat Tg(Myog-Ntf3)5160Wds/0	involves: 129S1/Sv	MGI:3052169
cx3	Ntrk1^tm2(Ntrk3)Apat/Ntrk1^tm2(Ntrk3)Apat Ntrk3^tm1Bbd/Ntrk3^tm1Bbd	involves: 129S1/Sv	MGI:3052171
cx4	Bax^tm1Sjk/Bax^tm1Sjk Ntrk1^tm2(Ntrk3)Apat/Ntrk1^tm2(Ntrk3)Apat	involves: 129S1/Sv * 129X1/SvJ	MGI:3052170

Genotype
MGI:3052168

hm1

• Allelic Composition: Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:92099 )

• homozygotes die before reaching adulthood

behavior/neurological

abnormal pain threshold ( J:92099 )

• homozygotes do not respond to painful stimuli at birth

nervous system

increased muscle spindle number ( J:92099 )

• as a result of the increase in proprioceptive neurons the number of muscle spindles is increased 2 - 3 fold in some muscle groups

decreased sensory neuron number ( J:92099 )

• the overall number of sensory neurons is decreased however the number of proprioceptive neurons is increased compared to Ntrk1^tm1Apat homozygotes

abnormal proprioceptive neuron morphology ( J:92099 )

• the overall number of sensory neurons is decreased however the number of proprioceptive neurons is increased compared to Ntrk1^tm1Apat homozygotes

muscle

increased muscle spindle number ( J:92099 )

• as a result of the increase in proprioceptive neurons the number of muscle spindles is increased 2 - 3 fold in some muscle groups

Genotype
MGI:3052169

cx2

• Allelic Composition: Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}; Tg(Myog-Ntf3)5160Wds/0
• Genetic Background: involves: 129S1/Sv

nervous system

abnormal proprioceptive neuron morphology ( J:92099 )

• a synergistic increase in the number of proprioceptive neurons is seen compared to either allele alone including a 7 fold or 11 fold increase in soleus muscle spindles compared to either Tg(Myog-Ntf3)5160Wds transgenic or wild-type mice respectively

Genotype
MGI:3052171

cx3

• Allelic Composition: Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}; Ntrk3^tm1Bbd/Ntrk3^tm1Bbd
• Genetic Background: involves: 129S1/Sv

nervous system

absent proprioceptive neurons ( J:92099 )

• dorsal root ganglia do not contain any proprioceptive neurons

Genotype
MGI:3052170

cx4

• Allelic Composition: Bax^tm1Sjk/Bax^tm1Sjk; Ntrk1^{tm2(Ntrk3)Apat}/Ntrk1^{tm2(Ntrk3)Apat}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

nervous system

increased muscle spindle number ( J:92099 )

• a 7-fold increase in the number of muscle spindles in the soleus muscle compared to Bax^tm1Sjk homozygotes

abnormal proprioceptive neuron morphology ( J:92099 )

• a 5-fold increase in the number of proprioceptive neurons in the soleus muscle compared to Bax^tm1Sjk homozygotes

muscle

increased muscle spindle number ( J:92099 )

• a 7-fold increase in the number of muscle spindles in the soleus muscle compared to Bax^tm1Sjk homozygotes