Islr2^tm1.1Ddg
Targeted Allele Detail

Summary

• Symbol: Islr2^tm1.1Ddg
• Name: immunoglobulin superfamily containing leucine-rich repeat 2; targeted mutation 1.1, David D Ginty
• MGI ID: MGI:4413447
• Synonyms: Linx^tEGFP
• Gene: Islr2 Location: Chr9:58103580-58111602 bp, - strand Genetic Position: Chr9, 31.63 cM
• Alliance: Islr2^tm1.1Ddg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154926
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 3 was replaced with Tau (Mapt)/EGFP fusion, a polyadenylation sequence, and floxed neo cassette. Germ line, cre mediated recombination removed the neo cassette. Reduced protein expression was confirmed by western blot analysis on brain extracts. (J:154926)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Islr2 Mutation: 24 strains or lines available

References

• Original: J:154926 Mandai K, et al., LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron. 2009 Sep 10;63(5):614-27
• All: 2 reference(s)