About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CMV-cre)1Cgn
transgene insertion 1, University of Cologne
MGI:2176180
Summary 54 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Abcc6tm1c(EUCOMM)Wtsi/Abcc6tm1c(EUCOMM)Wtsi
Tg(CMV-cre)1Cgn/?
B6.Cg-Abcc6tm1c(EUCOMM)Wtsi Tg(CMV-cre)1Cgn MGI:6241496
cn2
Braftm2Cpri/Braf+
Tg(CMV-cre)1Cgn/0
B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn MGI:5440072
cn3
Calcrtm1Rda/Calcrtm1Rda
Tg(CMV-cre)1Cgn/0
B6.Cg-Calcrtm1Rda Tg(CMV-cre)1Cgn MGI:4353058
cn4
Rasa3tm1a(KOMP)J/Rasa3tm1a(KOMP)J
Tg(CMV-cre)1Cgn/?
(C57BL/6N-Rasa3tm1a(KOMP)J/J x B6.C-Tg(CMV-cre)1Cgn/J)F2 MGI:6510851
cn5
Errfi1tm3.1Gvw/Errfi1tm3.1Gvw
Tg(CMV-cre)1Cgn/0
involves: 129 * 129S4/SvJaeSor * BALB/cJ MGI:5575863
cn6
Abcd1tm1Kan/Y
Gt(ROSA)26Sortm2.1(CAG-ELOVL1)Geno/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
involves: 129 * BALB/cJ * C57BL/6J * Swiss MGI:6196586
cn7
Prnptm1Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ MGI:3053021
cn8
Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ MGI:3053024
cn9
Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ MGI:3053022
cn10
Prnptm2Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
involves: 129P2/OlaHsd * BALB/cJ MGI:3053025
cn11
Braftm1Cpri/Braf+
Tg(CMV-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:3617227
cn12
Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(CMV-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:3706580
cn13
Ehmt1tm1.2Tara/Ehmt1+
Tg(CMV-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 MGI:4418572
cn14
Tigartm1.1Khv/Tigartm1.1Khv
Tg(CMV-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL MGI:5523243
cn15
Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(CMV-cre)1Cgn/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:5439643
cn16
Pygo1tm1Ssp/Pygo1tm1Ssp
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ MGI:3711494
cn17
Pygo2tm1.1Ssp/Pygo2tm1.1Ssp
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ MGI:3711495
cn18
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss MGI:3713466
cn19
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3582835
cn20
Pax3tm1Mrc/Pax3+
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3510830
cn21
Cdk4tm1.1Bbd/Cdk4+
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3582836
cn22
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/?
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J MGI:6510839
cn23
Mmp13tm1Werb/Mmp13tm1Werb
Tg(CMV-cre)1Cgn/0
involves: 129S2/SvPas * BALB/cJ * C57BL/6 MGI:3652794
cn24
Pax4tm1Pgr/Pax4tm1.1Aman
Tg(CMV-cre)1Cgn/0
involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL MGI:5466356
cn25
Tg(CMV-cre)1Cgn/0
Trp53tm2Att/Trp53+
involves: 129S4/SvJae * BALB/cJ MGI:3777014
cn26
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+
involves: 129S4/SvJae * BALB/cJ * C57BL/6J MGI:5750594
cn27
Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(CMV-cre)1Cgn/Y
involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:4836749
cn28
Exoc5tm1c(KOMP)Mbp/Exoc5tm1c(KOMP)Mbp
Tg(CMV-cre)1Cgn/0
involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N MGI:5774938
cn29
Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0
involves: 129S5/SvEvBrd * BALB/cJ MGI:3618178
cn30
Adamts4tm1Lex/Adamts4tm1.1Lex
Tg(CMV-cre)1Cgn/?
involves: 129S5/SvEvBrd * BALB/cJ MGI:3710667
cn31
Adamts4tm1Lex/Adamts4tm1Lex
Tg(CMV-cre)1Cgn/0
involves: 129S5/SvEvBrd * BALB/cJ MGI:3618176
cn32
Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/?
involves: 129S5/SvEvBrd * BALB/cJ MGI:3710666
cn33
Myh10tm5Rsad/Myh10tm5Rsad
Tg(CMV-cre)1Cgn/0
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:3702183
cn34
Med12tm1.1Hsch/Med12+
Tg(CMV-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6 MGI:4839553
cn35
Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:6269420
cn36
Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Tg(Dct-lacZ)#Ove/0
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N MGI:6269442
cn37
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0
involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:5524043
cn38
Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(CMV-cre)1Cgn/0
involves: 129/Sv * BALB/cJ * C57BL/6 MGI:6275802
cn39
Artm1Jdz/Y
Tg(CMV-cre)1Cgn/0
involves: 129X1/SvJ * BALB/cJ MGI:4431167
cn40
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(CMV-cre)1Cgn/0
involves: 129X1/SvJ * BALB/cJ * C57BL/6 MGI:3696483
cn41
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(CMV-cre)1Cgn/0
involves: BALB/c * C57BL/6 MGI:5525099
cn42
Glp1rtm1.1Stof/Glp1rtm1.1Stof
Tg(CMV-cre)1Cgn/0
involves: BALB/c * C57BL/6 * SJL MGI:5551464
cn43
Pax7tm1.1Thbr/Pax7tm1.1Thbr
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ MGI:5548070
cn44
Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ MGI:3844642
cn45
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ MGI:3844640
cn46
Padi4tm1.1Kmow/Padi4tm1.1Kmow
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ * C57BL/6 MGI:5451198
cn47
Tinf2tm2.1Tdl/Tinf2+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ * C57BL/6 MGI:5556240
cn48
Wlstm1.1Arte/Wlstm1.1Arte
Tg(CMV-cre)1Cgn/?
involves: BALB/cJ * C57BL/6 MGI:5547814
cn49
Pmltm1(PML/RARA)Ley/Pml+
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ * C57BL/6 MGI:5014086
cn50
Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)3Roer/0
involves: BALB/cJ * C57BL/6 MGI:4942366
cn51
Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)1Roer/0
involves: BALB/cJ * C57BL/6 MGI:4942365
cn52
Ano9em1Uoh/Ano9em1.1Uoh
Tg(CMV-cre)1Cgn/0
involves: BALB/cJ * C57BL/6 MGI:7581987
cn53
Creld1tm1c(EUCOMM)Wtsi/Creld1tm1c(EUCOMM)Wtsi
Tg(CMV-cre)1Cgn/?
involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL MGI:7546785
cx54
Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Tg(CMV-cre)1Cgn/?
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss MGI:3713467


Genotype
MGI:6241496
cn1
Allelic
Composition
Abcc6tm1c(EUCOMM)Wtsi/Abcc6tm1c(EUCOMM)Wtsi
Tg(CMV-cre)1Cgn/?
Genetic
Background
B6.Cg-Abcc6tm1c(EUCOMM)Wtsi Tg(CMV-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc6tm1c(EUCOMM)Wtsi mutation (1 available); any Abcc6 mutation (74 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

integument
• calcification of the fibrous capsule surrounding the muzzle vibrissae occurs at 20 weeks of age

growth/size/body

craniofacial




Genotype
MGI:5440072
cn2
Allelic
Composition
Braftm2Cpri/Braf+
Tg(CMV-cre)1Cgn/0
Genetic
Background
B6.Cg-Braftm2Cpri Tg(CMV-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm2Cpri mutation (0 available); any Braf mutation (58 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 70% of mice survive to adulthood with some mice lost after weaning

cardiovascular system

immune system
• in most mice
• 4-fold in most mice
• one mouse exhibits hyperplasia of lymphoid tissue at 73 weeks

neoplasm
• one mouse exhibits small intestinal adenoma at 79 weeks
• predisposition in aged mice

vision/eye
• including cataracts and watery eyes in some mice
• in some mice

craniofacial
• facial dysmorphia
• in some mice

growth/size/body
• facial dysmorphia
• in some mice
• in most mice
• 4-fold in most mice

muscle

nervous system

reproductive system
• one mouse exhibits hyperplasia of the smooth muscles of the uterus at 23 weeks
• in some mice

digestive/alimentary system
• predisposition in aged mice
• one mouse exhibits small intestinal adenoma at 79 weeks

hematopoietic system
• in most mice
• 4-fold in most mice

integument
• predisposition in aged mice

homeostasis/metabolism

skeleton
• in some mice




Genotype
MGI:4353058
cn3
Allelic
Composition
Calcrtm1Rda/Calcrtm1Rda
Tg(CMV-cre)1Cgn/0
Genetic
Background
B6.Cg-Calcrtm1Rda Tg(CMV-cre)1Cgn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calcrtm1Rda mutation (2 available); any Calcr mutation (58 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• levels are increased to 40 and 34 pg/ml in male and female mice from basal levels of less than 5 pg/ml in controls
• mice have higher rises in serum calcium level when administered calcitrol (active form of vitamin D) than controls
• rise in serum calcium is 44% higher in males and 21% higher in females

immune system
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin

limbs/digits/tail
• femur length in male mice is 4% shorter than controls at 6, 12, and 24 weeks of age

skeleton
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin
• femur length in male mice is 4% shorter than controls at 6, 12, and 24 weeks of age
• the trabecular structures in female mice are more rod-like than plate-like
• trabecular separation in the vertebrae of male mice is increased compared to controls
• trabecular bone formation is increased 20-40% in the femur of male mice
• trabecular bone volume in vertebrae of female mice is reduced by 6% at 6 weeks of age
• however, female mice do not have vertebrae trabecular bone loss as the age as controls do leading to 27% increase in bone volume by 24 weeks of age
• also, connectivity density is doubled in trabecular bone
• in female femur, trabecular thickness is decreased by 11% compared to controls

hematopoietic system
• bone marrow derived osteoclasts fail to dissemble actin rings in response to calcitonin




Genotype
MGI:6510851
cn4
Allelic
Composition
Rasa3tm1a(KOMP)J/Rasa3tm1a(KOMP)J
Tg(CMV-cre)1Cgn/?
Genetic
Background
(C57BL/6N-Rasa3tm1a(KOMP)J/J x B6.C-Tg(CMV-cre)1Cgn/J)F2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1a(KOMP)J mutation (1 available); any Rasa3 mutation (62 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• severe hemorrhage found in E12.5-E13.5 homozygotes

liver/biliary system
• small, pale fetal liver at E12.5-E13.5

integument

mortality/aging
• intercrosses of heterozygotes in the presence of a cre deleter yield no homozygous null animals at birth, showing the homozygous lethality and phenotypes of the null allele




Genotype
MGI:5575863
cn5
Allelic
Composition
Errfi1tm3.1Gvw/Errfi1tm3.1Gvw
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129 * 129S4/SvJaeSor * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Errfi1tm3.1Gvw mutation (1 available); any Errfi1 mutation (18 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Osteoarthritis-like disorder in Errfi1tm3.1Gvw/Errfi1tm3.1Gvw Tg(CMV-cre)1Cgn/0 knee joints

mortality/aging
• most die by 6 months of age

skeleton
• develop an osteoarthritis like phenotype in multiple synovial joints including the knee, ankle and temporal-mandibular joint
• ankles show extensive changes including swelling, stiffness, osteophytes
• in ankles
• in knee joints of 3.6 months old animals
• osteophytes in knee joints of 3 months to 1 year old animals

immune system
• develop an osteoarthritis like phenotype in multiple synovial joints including the knee, ankle and temporal-mandibular joint

homeostasis/metabolism
• in ankles




Genotype
MGI:6196586
cn6
Allelic
Composition
Abcd1tm1Kan/Y
Gt(ROSA)26Sortm2.1(CAG-ELOVL1)Geno/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129 * BALB/cJ * C57BL/6J * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcd1tm1Kan mutation (1 available); any Abcd1 mutation (14 available)
Gt(ROSA)26Sortm2.1(CAG-ELOVL1)Geno mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit very-long-chain fatty acid accumulation in different lipid classes and acylcarnitines
• total C26:0 levels are increased 20-fold in brain, 44-fold in adrenals, 90-fold in testes, 14-fold in lung, 14-fold in liver and 11-fold in kidney

mortality/aging
• fewer than the expected number of males are obtained (6% vs the expected 25%), however time is not specified




Genotype
MGI:3053021
cn7
Allelic
Composition
Prnptm1Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (150 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that in wild-type mice




Genotype
MGI:3053024
cn8
Allelic
Composition
Prnptm2Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Edin mutation (7 available); any Prnp mutation (150 available)
Prnptm2Tuzi mutation (0 available); any Prnp mutation (150 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no signs of TSE disease are seen 520 days postinfection an increased incubation time compared to wild-type or or mutants without cre recombination




Genotype
MGI:3053022
cn9
Allelic
Composition
Prnptm1Tuzi/Prnptm2Edin
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Tuzi mutation (0 available); any Prnp mutation (150 available)
Prnptm2Edin mutation (7 available); any Prnp mutation (150 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following cre recombination to remove the stop signal TSE strain ME7 incubation time is similar to that heterozygous Prnptm2Edin mice




Genotype
MGI:3053025
cn10
Allelic
Composition
Prnptm2Tuzi/Prnp+
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm2Tuzi mutation (0 available); any Prnp mutation (150 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• an increased incubation time for TSE strain ME7 compared to wild-type mice or mutants without cre recombination is seen




Genotype
MGI:3617227
cn11
Allelic
Composition
Braftm1Cpri/Braf+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Cpri mutation (0 available); any Braf mutation (58 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos with high levels of Cre mediated recombination are in the process of being resorbed at E7.5, while those with more mosaic recombination survived to later ages but still die before birth




Genotype
MGI:3706580
cn12
Allelic
Composition
Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2(Nfkbia)Rsu mutation (0 available); any Ctnnb1 mutation (49 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• authors state the they observe all phenotypic features of heterozygous Ctnnb1tm1(Nfkbia)Rsu mutants in these mice, however no data is presented in J:71744

immune system

vision/eye

growth/size/body
• about 50-70% of wild-type

endocrine/exocrine glands
• atrophy of Harderian glands

hearing/vestibular/ear

digestive/alimentary system
• reduction in the number of intestinal goblet cells
• the epithelial structure of the small intestine is loosened

cardiovascular system

craniofacial

hematopoietic system

liver/biliary system
• in embryos only

reproductive system

skeleton

limbs/digits/tail

behavior/neurological

integument
• patchy alopecia in older mice
• thin fur

cellular
• reduction in the number of intestinal goblet cells
• in embryos only

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
otitis media DOID:10754 J:71744




Genotype
MGI:4418572
cn13
Allelic
Composition
Ehmt1tm1.2Tara/Ehmt1+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt1tm1.2Tara mutation (0 available); any Ehmt1 mutation (90 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decrease in distance traveled and vertical activity in a new environment
• in a new environment
• in a new environment




Genotype
MGI:5523243
cn14
Allelic
Composition
Tigartm1.1Khv/Tigartm1.1Khv
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Tigartm1.1Khv mutation (0 available); any Tigar mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system

immune system




Genotype
MGI:5439643
cn15
Allelic
Composition
Fbn1tm1.1Itl/Fbn1tm3Rmz
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1.1Itl mutation (1 available); any Fbn1 mutation (171 available)
Fbn1tm3Rmz mutation (1 available); any Fbn1 mutation (171 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

respiratory system

homeostasis/metabolism




Genotype
MGI:3711494
cn16
Allelic
Composition
Pygo1tm1Ssp/Pygo1tm1Ssp
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and have no obvious phenotype




Genotype
MGI:3711495
cn17
Allelic
Composition
Pygo2tm1.1Ssp/Pygo2tm1.1Ssp
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.1Ssp mutation (1 available); any Pygo2 mutation (24 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die neonatally

vision/eye
• in all day-of-birth mice lenses were small or absent
• in all day-of-birth mice lenses were small or absent
• optic cups are misshapen with abnormal retinal folds and excess mesenchyme cells
• however, retinal differentiation and retinal pigment epithelium are grossly normal

renal/urinary system
• mild kidney development defects

growth/size/body
• mice are smaller late gestation




Genotype
MGI:3713466
cn18
Allelic
Composition
Pygo2tm1.2Ssp/Pygo2tm1.2Ssp
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo2tm1.2Ssp mutation (0 available); any Pygo2 mutation (24 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are born but with rare exceptions die shortly afterwards

renal/urinary system
• at high penetrance
• at E18.5, mesenchyme surrounding the ureteric buds is thickened 30% and ureteric tips are dilated and misshaped
• however, nephrogenesis is normal

vision/eye
• at high penetrance

growth/size/body
• at low penetrance
• at high penetrance
• at high penetrance

nervous system
• at low penetrance

craniofacial
• at low penetrance

digestive/alimentary system
• at low penetrance




Genotype
MGI:3582835
cn19
Allelic
Composition
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (76 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants develop breathing difficulties after 7 - 8 months of age
• frequent embryonic lethality; however, a significant number of double mutants survive

neoplasm
• a large spectrum of multifocal lesions are seen in the lung including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes
• large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes
• histiocytic sarcoma and other sarcomas seen in 2 out of 20 and 3 out of 20 double mutants, respectively
• anal papillomas seen in 3 out of 20 double mutants

cellular
• MEFs expressing the oncogenic protein do not undergo proliferative senescence and proliferate continuously as immortal cells

respiratory system
• a large spectrum of multifocal lesions are seen in the lung including; small patches of bronchiolo-alveolar hyperplasias to large bronchiolo-alveolar adenomas that compress adjacent lung structures and appear to derive from type II pneumocytes
• large bronchiolo-alveolar adenocarcinomas that compress adjacent lung structures and appear to derive from type II pneumocytes
• double mutants develop breathing difficulties after 7 - 8 months of age




Genotype
MGI:3510830
cn20
Allelic
Composition
Pax3tm1Mrc/Pax3+
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax3tm1Mrc mutation (1 available); any Pax3 mutation (50 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• the frontal bone is absent
• dysgenesis of the nasal bone is seen

muscle

skeleton
• the frontal bone is absent
• dysgenesis of the nasal bone is seen
• midline fusion of the sternum is incomplete
• multiple rib fusions are seen
• multiple vertebral fusions are seen

vision/eye
• the optic placode is present at E8.75 but completely degenerated by E12.5

nervous system
• disorganized, ectopic midbrain hyperplasia of neuroectodermal precursors is seen by E12.5
• forebrain hypoplasia is visible at E9.75
• the cortex is disorganized
• olfactory lobe agenesis is seen
• the dorsal root ganglia is hyperplastic

growth/size/body
• dysgenesis of the nasal bone is seen

respiratory system
• dysgenesis of the nasal bone is seen




Genotype
MGI:3582836
cn21
Allelic
Composition
Cdk4tm1.1Bbd/Cdk4+
Krastm1Bbd/Kras+
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1.1Bbd mutation (0 available); any Cdk4 mutation (57 available)
Krastm1Bbd mutation (2 available); any Kras mutation (76 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4tm1.1Bbd mutant mice is not accelerated
• histiocytic sarcoma and other sarcomas are seen
• anal papillomas are seen

digestive/alimentary system
• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

endocrine/exocrine glands
• focal metaplasia in the pancreatic ducts consisting of tall columnar cells with abundant apical mucin resembling gastric surface epithelial cells

nervous system

respiratory system
• latency to develop lung adenomas is significantly shorter compared to double mutants wild-type for Cdk4; however development of tumors characteristic of Cdk4tm1.1Bbd mutant mice is not accelerated




Genotype
MGI:6510839
cn22
Allelic
Composition
Rasa3tm1.1Llp/Rasa3tm1.3Llp
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/SvImJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rasa3tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)
Rasa3tm1.3Llp mutation (0 available); any Rasa3 mutation (62 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• intercrosses of heterozygotes in the presence of a cre deleter yield no homozygous null animals at birth, showing the homozygous lethality of the null allele




Genotype
MGI:3652794
cn23
Allelic
Composition
Mmp13tm1Werb/Mmp13tm1Werb
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S2/SvPas * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmp13tm1Werb mutation (1 available); any Mmp13 mutation (33 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• epidermal architecture and dermal composition are normal and show no differences in efficiency of re-epithelialization, inflammatory response, granulation tissue formation, angiogenesis, and restoration of basement membrane, indicating that skin homeostasis and tissue remodeling processes are normal




Genotype
MGI:5466356
cn24
Allelic
Composition
Pax4tm1Pgr/Pax4tm1.1Aman
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S2/SvPas * BALB/cJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax4tm1.1Aman mutation (0 available); any Pax4 mutation (26 available)
Pax4tm1Pgr mutation (0 available); any Pax4 mutation (26 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice die at birth after a cross to transgenic mice expressing CMV-cre
• some mice die within a few days of birth after a cross to transgenic mice expressing CMV-cre

endocrine/exocrine glands
• after a cross to transgenic mice expressing CMV-cre
• after a cross to transgenic mice expressing CMV-cre
• after a cross to transgenic mice expressing CMV-cre




Genotype
MGI:3777014
cn25
Allelic
Composition
Tg(CMV-cre)1Cgn/0
Trp53tm2Att/Trp53+
Genetic
Background
involves: 129S4/SvJae * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Trp53tm2Att mutation (0 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no viable adults are found and no postnatal lethality is detected suggesting mice die in the prenatal period




Genotype
MGI:5750594
cn26
Allelic
Composition
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+
Genetic
Background
involves: 129S4/SvJae * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Trp53tm4Att mutation (1 available); any Trp53 mutation (232 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• 83% of hearts exhibit outflow tract defects such as persistent truncus arteriosus and double outlet right ventricle
• in 33% of E12.5 embryos
• atrioventricular cushions fail to undergo remodeling

cellular
• increase in apoptosis in the retina, neural crest cells, the thymus, neuroepithelium, and otic vesicles
• decrease in proliferation in the retina, neural crest cells, the thymus, neuroepithelium, and otic vesicles

craniofacial
• E13.5 or older embryos commonly exhibit craniofacial defects, including square-shaped faces, short lower jaws, cleft lip and cleft palate
• short lower jaws 74% of embryos
• square-shaped faces in some E13.5 or older embryos
• in some E13.5 or older embryos
• in some E13.5 or older embryos
• protruding tongue due to short jaw
• 41% of embryos exhibit defects in external ear formation

digestive/alimentary system
• in some E13.5 or older embryos
• protruding tongue due to short jaw

embryo
• neural tube closure defects

endocrine/exocrine glands

growth/size/body
• square-shaped faces in some E13.5 or older embryos
• in some E13.5 or older embryos
• in some E13.5 or older embryos
• protruding tongue due to short jaw
• 41% of embryos exhibit defects in external ear formation

hearing/vestibular/ear
• 41% of embryos exhibit defects in external ear formation
• 71% of embryos exhibit a spectrum of inner ear defects, ranging from mild (either truncated posterior semi-circular canal or fused to the common crus) to highly abnormal (extreme inner ear bone malformation)

hematopoietic system

immune system

limbs/digits/tail

mortality/aging
• embryonic lethality between E13.5 and E15.5

nervous system
• neural tube closure defects
• 63 % of E13.5 or older embryos exhibit exencephaly

renal/urinary system
• kidneys show branching defects

skeleton
• short lower jaws 74% of embryos
• reduction in bone density in the cranium, nasal cavity, ulna, humerus, mandible and femur
• delay in bone formation in embryos

vision/eye
• in 59% of embryos

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
CHARGE syndrome DOID:0050834 OMIM:214800
J:217080




Genotype
MGI:4836749
cn27
Allelic
Composition
Tfpitm1.1Rdsi/Tfpitm1.1Rdsi
Tg(CMV-cre)1Cgn/Y
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfpitm1.1Rdsi mutation (1 available); any Tfpi mutation (45 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5774938
cn28
Allelic
Composition
Exoc5tm1c(KOMP)Mbp/Exoc5tm1c(KOMP)Mbp
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Exoc5tm1c(KOMP)Mbp mutation (0 available); any Exoc5 mutation (36 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are found as early as E8.5




Genotype
MGI:3618178
cn29
Allelic
Composition
Adamts5tm1Lex/Adamts5tm1Lex
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1Lex mutation (2 available); any Adamts5 mutation (54 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal

immune system
• protected against inflammatory arthritis
• otherwise viable, fertile, and phenotypically normal




Genotype
MGI:3710667
cn30
Allelic
Composition
Adamts4tm1Lex/Adamts4tm1.1Lex
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts4tm1.1Lex mutation (0 available); any Adamts4 mutation (48 available)
Adamts4tm1Lex mutation (1 available); any Adamts4 mutation (48 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• cartilage formation is normal




Genotype
MGI:3618176
cn31
Allelic
Composition
Adamts4tm1Lex/Adamts4tm1Lex
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts4tm1Lex mutation (1 available); any Adamts4 mutation (48 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• viable, fertile, and phenotypically normal




Genotype
MGI:3710666
cn32
Allelic
Composition
Adamts5tm1Lex/Adamts5tm1.1Lex
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S5/SvEvBrd * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts5tm1.1Lex mutation (0 available); any Adamts5 mutation (54 available)
Adamts5tm1Lex mutation (2 available); any Adamts5 mutation (54 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice are fertile

skeleton
• aggrecan loss (as measured by loss of toiludine blue staining in the tibiofemoral joint) is significantly less (1.15+/-0.15 mean score compared to 1.94+/-0.13 in wild-type joints)
• tibial cartilage erosion is seen in 1 of 13 joints as compared to 5 of 14 wild-type joints




Genotype
MGI:3702183
cn33
Allelic
Composition
Myh10tm5Rsad/Myh10tm5Rsad
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10tm5Rsad mutation (0 available); any Myh10 mutation (95 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show reduced ability to maintain balance on rotarod; performance depends on rate of rotation, such that at low speeds, mice show no deficiency

nervous system
• small number of Purkinje cells have abnormal orientation deviating from normal orientation where cell bodies are perpendicular to the surface of the cerebellar cortex
• almost all cells show a marked decrease in branches and dendritic spines compared to wild-type
• cell bodies of some Purkinje cells are dissociated from the cerebellar Purkinje cell layer and ectopically located in molecular layer




Genotype
MGI:4839553
cn34
Allelic
Composition
Med12tm1.1Hsch/Med12+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med12tm1.1Hsch mutation (0 available); any Med12 mutation (6 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer female embryos from a cross of hemizygous males and homozygous cre expressing females at E13.5
• only one female in 16 live births

embryo
• neural tube defects of variable severity at E11.5 in females
• in 30% of E12.5 mice

nervous system
• neural tube defects of variable severity at E11.5 in females
• in 30% of E12.5 mice
• exencephaly and spina bifida in 63% of mice over E12.5

skeleton
• some calvarial bones missing

limbs/digits/tail
• in 18 of 22 mice

craniofacial
• some calvarial bones missing




Genotype
MGI:6269420
cn35
Allelic
Composition
Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (42 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele

integument
• mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele




Genotype
MGI:6269442
cn36
Allelic
Composition
Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Tg(Dct-lacZ)#Ove/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (42 available)
Tg(CMV-cre)1Cgn mutation (6 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice

integument
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice




Genotype
MGI:5524043
cn37
Allelic
Composition
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

nervous system
• Pomc+ neurons

growth/size/body

adipose tissue
• increased visceral fat mass

homeostasis/metabolism
• in ovariectomized mice




Genotype
MGI:6275802
cn38
Allelic
Composition
Lgi1tm2.1Jkc/Lgi1tm2.1Jkc
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129/Sv * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgi1tm2.1Jkc mutation (1 available); any Lgi1 mutation (32 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice develop seizures between P12 and P20

nervous system
• mice develop seizures between P12 and P20
• hypercellularity of neuronal cells in layers 2-4




Genotype
MGI:4431167
cn39
Allelic
Composition
Artm1Jdz/Y
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129X1/SvJ * BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Artm1Jdz mutation (1 available); any Ar mutation (22 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• testis weights at 3 weeks are significantly lower (3.5 mg) than control males (24.9-27 mg)

reproductive system
• testis weights at 3 weeks are significantly lower (3.5 mg) than control males (24.9-27 mg)




Genotype
MGI:3696483
cn40
Allelic
Composition
Gt(ROSA)26Sortm1Hjf/Gt(ROSA)26Sortm1(EYFP)Cos
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (935 available)
Gt(ROSA)26Sortm1Hjf mutation (5 available); any Gt(ROSA)26Sor mutation (935 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• analysis of hematopoietic cells demonstrates reliable detection of YFP and RFP in same cells as well as in different cells




Genotype
MGI:5525099
cn41
Allelic
Composition
Bcrtm1(BCR/ABL)Tsr/Bcr+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcrtm1(BCR/ABL)Tsr mutation (1 available); any Bcr mutation (51 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are born at expected Mendelian rations and do not exhibit any gross abnormalities




Genotype
MGI:5551464
cn42
Allelic
Composition
Glp1rtm1.1Stof/Glp1rtm1.1Stof
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glp1rtm1.1Stof mutation (1 available); any Glp1r mutation (49 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• after exendin-4 treatment, mice fail to exhibit a hypophagic response unlike control mice

homeostasis/metabolism
• sham operated mice tended to be more glucose-intolerant than control mice

growth/size/body
N
• after vertical sleeve gastrectomy, mice exhibit normal weight changes




Genotype
MGI:5548070
cn43
Allelic
Composition
Pax7tm1.1Thbr/Pax7tm1.1Thbr
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• authors state that mice phenocopy Pax7tm2Pgr homozygotes




Genotype
MGI:3844642
cn44
Allelic
Composition
Gt(ROSA)26Sortm1(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slightly fewer than expected mice with this genotype are found

hematopoietic system
• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation




Genotype
MGI:3844640
cn45
Allelic
Composition
Gt(ROSA)26Sortm2(Nfatc2*)Rao/Gt(ROSA)26Sor+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(Nfatc2*)Rao mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice with this genotype are found

hematopoietic system
• the fraction of B and T cells expressing the recombined allele decreases during differentiation and maturation




Genotype
MGI:5451198
cn46
Allelic
Composition
Padi4tm1.1Kmow/Padi4tm1.1Kmow
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Padi4tm1.1Kmow mutation (2 available); any Padi4 mutation (40 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• bone marrow-derived mast cells exhibit normal ATP-stimulated citrullination




Genotype
MGI:5556240
cn47
Allelic
Composition
Tinf2tm2.1Tdl/Tinf2+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Tinf2tm2.1Tdl mutation (1 available); any Tinf2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice weigh slightly less than wild type littermates at weaning and 6 months of age

mortality/aging
• mutants are born at a lower than expected frequency (35%)




Genotype
MGI:5547814
cn48
Allelic
Composition
Wlstm1.1Arte/Wlstm1.1Arte
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Wlstm1.1Arte mutation (0 available); any Wls mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die mid-gestation




Genotype
MGI:5014086
cn49
Allelic
Composition
Pmltm1(PML/RARA)Ley/Pml+
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pmltm1(PML/RARA)Ley mutation (1 available); any Pml mutation (91 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4942366
cn50
Allelic
Composition
Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)3Roer/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Tg(Kit*D814V)3Roer mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only about 25% of mice survive to adulthood
• surviving mice show signs of spontaneous regression of the hyperproliferative dysregulation of erythropoiesis
• rapid lethality in about 75% of neonatal mice

hematopoietic system
• mice appear to die of hyperproliferative dysregulation of erythropoiesis
• dramatic dysregulation of hematopoiesis characterized by excessive numbers of nucleated cells in the peripheral blood
• increase in nucleated cells is primarily the result of a population of small blastic cells with sparse cytoplasm
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)3Roer and Tg(Mx1-cre)1Cgn
• increase in the number of nuclear shadows in blood smears indicates the presence of cells with increased mechanical fragility

liver/biliary system
• most of the liver parenchyma is replaced with Ter119+ cells

immune system
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)3Roer and Tg(Mx1-cre)1Cgn




Genotype
MGI:4942365
cn51
Allelic
Composition
Tg(CMV-cre)1Cgn/0
Tg(Kit*D814V)1Roer/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CMV-cre)1Cgn mutation (6 available)
Tg(Kit*D814V)1Roer mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only about 25% of mice survive to adulthood
• surviving mice show signs of spontaneous regression of the hyperproliferative dysregulation of erythropoiesis
• rapid lethality in about 75% of neonatal mice

digestive/alimentary system
• survivors develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn

hematopoietic system
• mice appear to die of hyperproliferative dysregulation of erythropoiesis
• dramatic dysregulation of hematopoiesis characterized by excessive numbers of nucleated cells in the peripheral blood
• increase in nucleated cells is primarily the result of a population of small blastic cells with sparse cytoplasm
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• increase in the number of nuclear shadows in blood smears indicates the presence of cells with increased mechanical fragility

liver/biliary system
• most of the liver parenchyma is replaced with Ter119+ cells

immune system
• survivors develop intestinal inflammation similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn
• survivors develop mastocytosis similar to that in mice carrying Tg(Kit*D814V)1Roer and Tg(Mx1-cre)1Cgn




Genotype
MGI:7581987
cn52
Allelic
Composition
Ano9em1Uoh/Ano9em1.1Uoh
Tg(CMV-cre)1Cgn/0
Genetic
Background
involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano9em1.1Uoh mutation (0 available); any Ano9 mutation (41 available)
Ano9em1Uoh mutation (0 available); any Ano9 mutation (41 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
• freshly isolated olfactory sensory neurons elicit cAMP-evoked currents with markedly reduced amplitudes
• reduced electro-olfactogram responses to odorant containing air puffs
• olfactory bulb responses (calcium signals) are significantly reduced compared to controls

behavior/neurological
• fail to show a preference for peanut butter odor
• fail to show an aversive reaction to 2-methyl butyric acid
• following reward training, fail to show preference for the trained scent, carvone

nervous system
• freshly isolated olfactory sensory neurons elicit cAMP-evoked currents with markedly reduced amplitudes

respiratory system
• freshly isolated olfactory sensory neurons elicit cAMP-evoked currents with markedly reduced amplitudes




Genotype
MGI:7546785
cn53
Allelic
Composition
Creld1tm1c(EUCOMM)Wtsi/Creld1tm1c(EUCOMM)Wtsi
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: BALB/cJ * C57BL/6 * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creld1tm1c(EUCOMM)Wtsi mutation (0 available); any Creld1 mutation (30 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous embryos are present at Mendelian ratios at E10.0-E10.5 but die soon after; no viable homozygotes are recovered after E11.5




Genotype
MGI:3713467
cx54
Allelic
Composition
Pygo1tm1.1Ssp/Pygo1tm1.1Ssp
Tg(CMV-cre)1Cgn/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1tm1.1Ssp mutation (0 available); any Pygo1 mutation (20 available)
Tg(CMV-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory