Lgi1^tm2.1Jkc
Targeted Allele Detail

Summary

• Symbol: Lgi1^tm2.1Jkc
• Name: leucine-rich repeat LGI family, member 1; targeted mutation 2.1, John K Cowell
• MGI ID: MGI:6275636
• Synonyms: LGI1 cKO, LGI1^flox
• Gene: Lgi1 Location: Chr19:38253135-38297387 bp, + strand Genetic Position: Chr19, 32.9 cM
• Alliance: Lgi1^tm2.1Jkc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269784
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3, and an FRT-flanked neomycin selection cassette followed by a second loxP site downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 3 thorugh 4 floxed. (J:269784)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lgi1 Mutation: 32 strains or lines available

References

• Original: J:269784 Silva J, et al., Selective inactivation of LGI1 in neuronal precursor cells leads to cortical dysplasia in mice. Genesis. 2018 Nov 29;:e23268
• All: 1 reference(s)