Ehmt1^tm1.2Tara
Targeted Allele Detail

Summary

• Symbol: Ehmt1^tm1.2Tara
• Name: euchromatic histone methyltransferase 1; targeted mutation 1.2, Alexander Tarakhovsky
• MGI ID: MGI:4418565
• Gene: Ehmt1 Location: Chr2:24680781-24809658 bp, - strand Genetic Position: Chr2, 16.73 cM
• Alliance: Ehmt1^tm1.2Tara page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:155739
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 23 was floxed and an FRT-flanked neo cassette was inserted into intron 23 via homologous recombination. The selection cassette and exon 23 were removed by flp and cre mediated recombination, respectively. Cre-mediated recombination results in out-of-frame splicing and nonsense mediated decay of the mutant transcript. (J:155739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehmt1 Mutation: 90 strains or lines available

References

• Original: J:155739 Schaefer A, et al., Control of cognition and adaptive behavior by the GLP/G9a epigenetic suppressor complex. Neuron. 2009 Dec 10;64(5):678-91
• All: 1 reference(s)