Gt(ROSA)26Sor^{tm2.1(CAG-ELOVL1)Geno}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2.1(CAG-ELOVL1)Geno}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Genoway
• MGI ID: MGI:6194785
• Synonyms: Rosa26^{CAG-STOPflox/flox-ELOVL1TG}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2.1(CAG-ELOVL1)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257393
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2.1(CAG-ELOVL1)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ELOVL1 (64834)

  Elovl1

  (MGI:1858959)

• Mutation details: GenOway's quick knock-in approach was used to introduce a loxP-flanked transcriptional STOP cassette and a single copy of the human ELOVL1 cDNA under the control of the CAG promoter into the Rosa26 locus through homologous recombination. Flp-mediated recombination removed a FRT-flanked neomycin cassette. (J:257393)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1046 strains or lines available

References

• Original: J:257393 van de Beek MC, et al., C26:0-Carnitine Is a New Biomarker for X-Linked Adrenoleukodystrophy in Mice and Man. PLoS One. 2016;11(4):e0154597
• All: 1 reference(s)