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Elovl1 Gene Detail
Summary
  • Symbol
    Elovl1
  • Name
    ELOVL fatty acid elongase 1
  • Synonyms
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1, Ssc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858959
    NCBI Gene: 54325
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118285321-118290150 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 54.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858959
protein coding gene Chr4:118285290-118290150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028667
protein coding gene Chr4:119485050-119489557 (+)
A/J MGP_AJ_G0028628
protein coding gene Chr4:114849955-114854529 (+)
AKR/J MGP_AKRJ_G0028578
protein coding gene Chr4:117354398-117358488 (+)
BALB/cJ MGP_BALBcJ_G0028649
protein coding gene Chr4:115490953-115495478 (+)
C3H/HeJ MGP_C3HHeJ_G0028363
protein coding gene Chr4:118933659-118938177 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029090
protein coding gene Chr4:124049538-124054129 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026374
protein coding gene Chr4:108869068-108873959 (+)
CAST/EiJ MGP_CASTEiJ_G0027797
protein coding gene Chr4:116192710-116197303 (+)
CBA/J MGP_CBAJ_G0028330
protein coding gene Chr4:127457389-127461915 (+)
DBA/2J MGP_DBA2J_G0028478
protein coding gene Chr4:115460913-115465498 (+)
FVB/NJ MGP_FVBNJ_G0028446
protein coding gene Chr4:113979658-113984602 (+)
LP/J MGP_LPJ_G0028580
protein coding gene Chr4:119665256-119669845 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028473
protein coding gene Chr4:132337757-132342262 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029127
protein coding gene Chr4:118518992-118523577 (+)
PWK/PhJ MGP_PWKPhJ_G0027523
protein coding gene Chr4:112293070-112297710 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027346
protein coding gene Chr4:114819594-114824181 (+)
WSB/EiJ MGP_WSBEiJ_G0027876
protein coding gene Chr4:118415196-118419703 (+)



Homology
more
  • Human Ortholog
    ELOVL1, ELOVL fatty acid elongase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELOVL1, ELOVL fatty acid elongase 1
  • Synonyms
    CGI-88, IKSHD, Ssc1
  • Links
    NCBI Gene ID: 64834
    neXtProt AC: NX_Q9BW60
    UniProt: Q9BW60

  • Chr Location
    1p34.2; chr1:43363398-43368074 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    2
  • Genomic Mutations
    4 involving Elovl1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a targeted allele exhibit complete neonatal lethality, abnormal skin morphology, impaired skin barrier function, decreased weight and impaired formation of very long chain fatty acids.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54325 NCBI Gene Model | MGI Sequence Detail 4830 C57BL/6J ±  kb
transcript NM_001424988 RefSeq | MGI Sequence Detail 3167 C57BL/6  
polypeptide Q9JLJ5 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 16
    Primer pair 5

    Microarray probesets 6
Other
Accession IDs
less
MGI:2140119, MGI:2140640
References
more
  • Summaries
    All 57
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 20
  • Earliest
    J:170151 LORCH J, Note on the cytological localization of alkaline phosphatase. Q J Microsc Sci. 1947 Jun;88(Pt 2):159-61
  • Latest
    J:335285 Sassa T, et al., Involvement of omega-O-acylceramides and protein-bound ceramides in oral permeability barrier formation. Cell Rep. 2023 Apr 5;:112363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
09/24/2024
MGI 6.24
The Jackson Laboratory