Pax3tm1Mrc
Targeted Allele Detail
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Symbol: |
Pax3tm1Mrc |
Name: |
paired box 3; targeted mutation 1, Mario R Capecchi |
MGI ID: |
MGI:3487369 |
Synonyms: |
Pax3:Fkhr, Pax3:Foxo1, Pax3P3Fm |
Gene: |
Pax3 Location: Chr1:78077904-78173771 bp, - strand Genetic Position: Chr1, 39.79 cM
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Alliance: |
Pax3tm1Mrc page
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Allele Type: |
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Targeted (Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Mutation details: A targeting vector was inserted into the 3' region of the gene, resulting in loxP sites flanking exons 8-10 as well as an inserted polyA/stop signal from the C2 gene and exons 2 and 3 of the Foxo1 gene (with an IRES-eYFP cassette in exon 3). Crossing with FLP expressing mice excised an FRT flanked neo that was also inserted downstream. The mutation allowed normal functioning until activation of Cre recombinase. Cre causes the fusion of exons 1-7 of Pax3 to a region of Foxo1 containing exons 2 and 3, as well as 6.5 kb of the UTR and genomic sequence. Simultaneously, an IRES-eYFP marker is expressed.
(J:93444)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Pax3tm1Mrc
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pax3 Mutation: |
50 strains or lines available
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Original: |
J:93444 Keller C, et al., Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26 |
All: |
15 reference(s) |
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