Gt(ROSA)26Sor^{tm1(CAG-SETBP1*G870S,-EGFP)Ase}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-SETBP1*G870S,-EGFP)Ase}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Alessandro Sessa
• MGI ID: MGI:8207504
• Synonyms: Rosa26-LoxP-STOP-LoxP-hSETBP1^G870S, SETBP1^LSL
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-SETBP1*G870S,-EGFP)Ase} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:363041
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-SETBP1*G870S,-EGFP)Ase} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SETBP1 (26040)

  Setbp1

  (MGI:1933199)

  Contains G870S mutation

• Mutation details: The targeting vector consisting of the CAG promoter, loxP-flanked STOP cassette, and human SETPBP1 coding sequence with a glycine to serine substitution at amino acid 870 (p.G870S) fused to the V5 tag, followed by an IRES and enhanced green fluorescent protein was inserted into the locus. The inserted sequence is only expressed after cre-mediated deletion of the STOP cassette. (J:363041)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1098 strains or lines available

References

• Original: J:363041 Crespiatico I, et al., First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis. Blood. 2024 Apr 4;143(14):1399-1413
• All: 2 reference(s)