Nhlh2^tm2Thbr
Targeted Allele Detail

Summary

• Symbol: Nhlh2^tm2Thbr
• Name: nescient helix loop helix 2; targeted mutation 2, Thomas Braun
• MGI ID: MGI:5524018
• Synonyms: NSCL-2^loxP
• Gene: Nhlh2 Location: Chr3:101917425-101922808 bp, + strand Genetic Position: Chr3, 44.3 cM
• Alliance: Nhlh2^tm2Thbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199640
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 3 was floxed. (J:199640)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nhlh2 Mutation: 13 strains or lines available

References

• Original: J:199640 Schmid T, et al., Loss of NSCL-2 in gonadotropin releasing hormone neurons leads to reduction of pro-opiomelanocortin neurons in specific hypothalamic nuclei and causes visceral obesity. J Neurosci. 2013 Jun 19;33(25):10459-70
• All: 3 reference(s)