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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nhlh2tm2Thbr
targeted mutation 2, Thomas Braun
MGI:5524018
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA MGI:5524048
cn2
 		Kiss1tm1.1(cre)Uboe/Kiss1+
Nhlh2tm2Thbr/Nhlh2tm2Thbr 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J MGI:5524042
cn3
 		Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0 		involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:5524043
cn4
 		Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA MGI:5524046
cn5
 		Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Pomc-EGFP)1Low/0
Tg(Pomc1-cre)16Lowl/0 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * FVB/N MGI:5524040
cn6
 		Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Agrp-cre)1Gsb/0 		involves: 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5524041


Genotype
MGI:5524048
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (944 available)
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neuron number ( J:199640 )
• Gnrh+ neurons in the medial preoptic area and posterior hypothalamus
ectopic neuron ( J:199640 )
• in the anterior olfactory nucleus




Genotype
MGI:5524042
cn2
Allelic
Composition		 Kiss1tm1.1(cre)Uboe/Kiss1+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kiss1tm1.1(cre)Uboe mutation (0 available); any Kiss1 mutation (21 available)
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:199640 )
N
• mice exhibit normal uteri weight

growth/size/body
growth/size/body region phenotype ( J:199640 )
N
• mice exhibit normal weight

adipose tissue
adipose tissue phenotype ( J:199640 )
N
• mice exhibit normal visceral fat depots




Genotype
MGI:5524043
cn3
Allelic
Composition		 Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

nervous system
decreased neuron number ( J:199640 )
• Pomc+ neurons

growth/size/body
increased body weight ( J:199640 )

adipose tissue
increased abdominal adipose tissue amount ( J:199640 )
• increased visceral fat mass

homeostasis/metabolism
decreased circulating estradiol level ( J:199640 )
• in ovariectomized mice




Genotype
MGI:5524046
cn4
Allelic
Composition		 Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:199640 )
N
• mice exhibit normal uteri and testis weights

nervous system
decreased neuron number ( J:199640 )
• severe reduction in Pomc+ neurons in the medial preoptic area and posterior hypothalamus in male and female mice
• reduced Gnhr+ neurons in male and female mice

adipose tissue
increased white adipose tissue amount ( J:199640 )
• increased visceral fat mass weight in male and female mice but not as much as in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
• however, subcutaneous adipose weight is normal

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:199640 )
N
• mice exhibit normal estradiol levels




Genotype
MGI:5524040
cn5
Allelic
Composition		 Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Pomc-EGFP)1Low/0
Tg(Pomc1-cre)16Lowl/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
Tg(Pomc-EGFP)1Low mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:199640 )
N
• mice exhibit normal uteri weight and fertility

nervous system
nervous system phenotype ( J:199640 )
N
• mice exhibit normal numbers of Gnrh+ neurons

growth/size/body
growth/size/body region phenotype ( J:199640 )
N
• mice exhibit normal weight

adipose tissue
adipose tissue phenotype ( J:199640 )
N
• mice exhibit normal visceral and subcutaneous fat depots




Genotype
MGI:5524041
cn6
Allelic
Composition		 Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Agrp-cre)1Gsb/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (13 available)
Tg(Agrp-cre)1Gsb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:199640 )
N
• mice exhibit normal uteri weight

growth/size/body
growth/size/body region phenotype ( J:199640 )
N
• mice exhibit normal weight

adipose tissue
adipose tissue phenotype ( J:199640 )
N
• mice exhibit normal visceral fat depots




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory