Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nhlh2tm2Thbr targeted mutation 2, Thomas Braun MGI:5524018 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Gnrh+ neurons in the medial preoptic area and posterior hypothalamus
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• in the anterior olfactory nucleus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal uteri weight
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| N |
• mice exhibit normal weight
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| N |
• mice exhibit normal visceral fat depots
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Pomc+ neurons
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• increased visceral fat mass
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• in ovariectomized mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal uteri and testis weights
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• severe reduction in Pomc+ neurons in the medial preoptic area and posterior hypothalamus in male and female mice
• reduced Gnhr+ neurons in male and female mice
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• increased visceral fat mass weight in male and female mice but not as much as in Nhlh2tm2Thbr/Nhlh2tm2Thbr Tg(CMV-cre)1Cgn mice
• however, subcutaneous adipose weight is normal
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N |
• mice exhibit normal estradiol levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• mice exhibit normal uteri weight and fertility
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| N |
• mice exhibit normal numbers of Gnrh+ neurons
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| N |
• mice exhibit normal weight
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| N |
• mice exhibit normal visceral and subcutaneous fat depots
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• mice exhibit normal uteri weight
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| N |
• mice exhibit normal weight
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| N |
• mice exhibit normal visceral fat depots
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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