Kiss1^{tm1.1(cre)Uboe}
Targeted Allele Detail

Summary

• Symbol: Kiss1^{tm1.1(cre)Uboe}
• Name: KiSS-1 metastasis-suppressor; targeted mutation 1.1, Ulrich Boehm
• MGI ID: MGI:4878876
• Synonyms: Kiss-Cre, KissIC, KissIC^neo-
• Gene: Kiss1 Location: Chr1:133254950-133257460 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Kiss1^{tm1.1(cre)Uboe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167285
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Kiss1^{tm1.1(cre)Uboe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Kiss1 (MGI:2663985)

• Mutation details: A targeting construct was used to insert an IRES-cre-FRT-pgk-neo-FRT cassette into the Kiss1 locus after exon 2. Properly targeted ES cell clones were injected into C57BL/6J blastcysts to produce KissIC^neo+ chimeras that were backcrossed to C57BL/6J animals. To remove the neo cassette, mice were bred to Flp deleter mice, then backcrossed to C57BL/6J for 6 generations. (J:167285)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kiss1 (mouse) Summary of all recombinase alleles driven by Kiss1. Alliance mouse Kiss1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1 Mutation: 21 strains or lines available

References

• Original: J:167285 Mayer C, et al., Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons. Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22693-8
• All: 18 reference(s)